阿司匹林联合阿托伐他汀治疗冠状动脉粥样硬化性心脏病效果观察及对血脂、炎性因子、生活质量的影响  

Effectiveness of Aspirin Combined with Atorvastatin in Adjuvant Treatment of Patients with Coronary Atherosclerotic Heart Disease and Its Effects on Blood Lipids, Inflammatory Factors and Quality of Life

作　　者：付静寨 王玉清 王翠平 王丽鸣 崔万申 孙宏超 及艳辉 魏伟华 高丽萍 FU Jing-zhai;WANG Yu-qing;WANG Cui-ping;WANG Li-ming;CUI Wan-shen;SUN Hong-chao;JI Yan-hui;WEI Wei-hua;GAO Li-ping(Department of Cardiology,People's Hospital of Renqiu,Renqiu,Hebei 062550,China;Department of Radiology,People's Hospital of Renqiu,Renqiu,Hebei 062550,China;Department of Cardiology,the Second People's Hospital of Renqiu,Renqiu,Hebei 062550,China;Department of Paediatrics,Maternal and Child Health Hospital of Yuanshi County,Yuanshi,Hebei 051130,China)

机构地区：[1]任丘市人民医院心内科,河北任丘062550 [2]任丘市人民医院放射科,河北任丘062550 [3]任丘市第二人民医院心内科,河北任丘062550 [4]元氏县妇幼保健院儿科,河北元氏051130

出　　处：《解放军医药杂志》2019年第11期80-83,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：河北省卫生厅科研基金项目(20181135);沧州市重点研发计划项目(172302015)

摘　　要：目的阿司匹林联合阿托伐他汀辅治冠状动脉粥样硬化性心脏病(冠心病)的效果及对血脂、炎性因子、生活质量的影响。方法选取2017年6月-2018年10月我院收治的冠心病患者112例,根据用药方法分为观察组和对照组,每组56例。对照组给予阿司匹林治疗,观察组在对照组基础上加用阿托伐他汀治疗。比较2组临床疗效;治疗前后总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平;评定2组生活质量改善情况及不良反应发生情况。结果观察组治疗总有效率高于对照组(P<0.05)。2组治疗后TC、TG、HDL-C、LDL-C水平和TNF-α、CRP水平均较治疗前改善,且观察组改善程度优于对照组(P<0.05)。2组治疗后QLQ-C30各维度评分均较治疗前改善,且观察组改善程度大于对照组(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论阿司匹林联合阿托伐他汀用于冠心病患者的辅助治疗,可显著提高临床疗效,降低血脂和炎性因子水平,有效改善患者生活质量,且治疗安全性好。Objective To investigate effectiveness of Aspirin combined with Atorvastatin in adjuvant treatment of patients with coronary atherosclerotic heart disease(coronary artery disease) and its effects on blood lipids, inflammatory factors and quality of life. Methods A total of 112 patients with coronary heart disease admitted during June 2017 and October 2018 were divided into observation group and control group(n=56 in each group) according to different medication methods, Control group was treated with Aspirin, while observation group was added with Atorvastatin on the basis of treatment for control group. In two groups, clinical effectiveness was compared;levels of total cholesterol(TC), triglyceride(TG), high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C), tumor necrosis factor-α(TNF-α) and C-reactive protein(CRP) before and after treatment were compared;conditions of improved quality of life and incidence rate of adverse reactions were evaluated. Results The total effective rate in observation group was significantly higher than that in control group(P<0.05). After treatment, levels of TC, TG, HDL-C, LDL-C, TNF-α and CRP were improved compared with those before treatment in two groups, and the improved conditions in observation group were better than those in control group(P<0.05). After treatment, QLQ-C30 scores were improved compared with those before treatment in two groups, and the improved degrees in observation group were more than those in control group(P<0.05). There was no significant difference in incidence rate of adverse reactions between two groups(P>0.05). Conclusion Aspirin combined with Atorvastatin can be used in adjuvant treatment of patients with coronary heart disease, and it may significantly improve clinical effectiveness, reduce levels of blood lipid and inflammatory factors and effectively improve quality of life of patients with good safety.

关 键 词：冠状动脉粥样硬化心脏病 阿司匹林 阿托伐他汀 血脂 炎性因子 

分 类 号：R541.4[医药卫生—心血管疾病]