晚发型重度子痫前期患者外周血Treg/Th17细胞亚群含量和妊娠结局分析  

Analysis of Relationship between Treg/Th17 Cell Subsets in Peripheral Blood and Pregnancy Outcomes in Patients with Late Severe Preeclampsia

作　　者：李燕君[1] 俄洛吉[1] LI Yan-jun;E Luo-ji(Department of Obstetrics,Qinghai Provincial People's Hospital,810001)

机构地区：[1]青海省人民医院产科,青海西宁810001

出　　处：《医学临床研究》2019年第10期1915-1917,共3页Journal of Clinical Research

摘　　要：【目的】探讨晚发型重度子痫前期患者外周血Treg/Th17细胞亚群含量和妊娠结局的关系.【方法】选取120例晚发型重度子痫前期患者作为观察组,另外选取同期入院行产前检查的正常晚期妊娠妇女40例作为对照组.采用流式细胞术检测两组外周血Treg、Th17细胞含量,分析两组妊娠结局与Treg/Th17细胞亚群的关系.【结果】观察组外周血Th17细胞水平显著高于对照组,Treg细胞水平显著低于对照组(P<0.05).观察组剖宫产率、子痫发生率、低体质量儿比例显著高于对照组(P<0.05),自然分娩率显著低于对照组(P<0.05).【结论】晚发型重度子痫前期患者外周血存在Treg、Th17细胞亚群紊乱,其剖宫产率、低体质量儿比例、子痫发生率显著高于正常妊娠妇女.【Objective】To investigate the relationship between Treg/Th17 cell subsets and pregnancy outcome in patients with later severe preeclampsia.【Methods】A total of 120 patients with severe late preeclampsia were collected as the observation group and 40 normal late pregnant women with prenatal examination in the same period were selected as the control group.The contents of Treg and Th17 cells in peripheral blood were measured by flow cytometry.The results of pregnancy outcome,neonatal outcome and complications in the two groups were compared.【Results】The level of Th17 cells in the peripheral blood of the observation group was significantly higher than that of the control group,and the level of Treg cells was significantly lower than that of the control group(P<0.05).The cesarean section rate in the observation group was significantly higher than that in the control group,and the natural delivery rate was significantly lower than that in the control group(P<0.05).The proportion of low birth weight infants in the observation group was significantly higher than that in the control group(P<0.05).The incidence of eclampsia in the observation group was significantly higher than that in the control group(P<0.05).【Conclusion】There are disorders of Treg and Th17 cell subsets in the peripheral blood of severe later preeclampsia patients.The cesarean section rate,the proportion of low birth weight infants and the incidence of eclampsia are significantly higher than those in normal pregnant women.

关 键 词：先兆子痫/诊断 TH17 细胞 妊娠结局 

分 类 号：R714.244[医药卫生—妇产科学]