过敏性紫癜患儿血清IgA1异常糖基化水平及其与氧化应激指标的相关性研究  

Abnormal Glycosylation of Serum IgA1 in Children with Henoch Schonlein Purpura Correlated with Oxidative Stress

作　　者：权春梅 任宗明[1] 王能勇 李莎[1] QUAN Chun-mei;REN Zong-ming;WANG Neng-yong(Sichuan Guangyuan Second People's Hospital,628000)

机构地区：[1]四川省广元市第二人民医院检验科,四川广元628000

出　　处：《医学临床研究》2019年第10期1918-1919,1922,共3页Journal of Clinical Research

摘　　要：【目的】探讨过敏性紫癜(HSP)患儿血清IgA1异常糖基化水平及其与氧化应激指标的相关性.【方法】116例在本院接受治疗的HSP患儿,其中单纯HSP患儿79例,过敏性紫癜肾炎(HSPN)患儿37例.选取同期体检的健康儿童30例为对照组.比较三组患儿血清IgA1和IgA1异常糖基化水平,血清超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH PX)、丙二醛(MDA)和晚期氧化蛋白产物(AOPPs)水平,并分析其相关性.【结果】对照组IgA1和IgA1异常糖基化水平低于单纯HSP组和HSPN组,而单纯HSP组又低于HSPN组,且差异均有显著性(均P<0.05).对照组SOD、GSH PX水平高于单纯HSP组和HSPN组,而单纯HSP组又高于HSPN组;对照组MDA、AOPPs水平低于单纯HSP组和HSPN组,而单纯HSP组又低于HSPN组(均P<0.05).Spearman分析显示IgA1和IgA1异常糖基化与SOD、GSH PX呈负相关(P<0.05),与MDA、AOPPs呈正相关(P<0.05).【结论】HSP患儿血清IgA1和IgA1异常糖基化水平升高,且与患儿氧化应激状态存在明显的相关性.【Objective】To investigate the abnormal glycosylation of serum IgA1 in children with Henoch Schonlein purpura(HSP)and reveal the correlation with oxidative stress.【Methods】A total of 116 children with HSP admitted to our hospital included 79 cases of simple HSP(HSP group)and 37 cases of Henoch Schonlein purpura nephritis(HSPN group).Volunteers of 30 healthy children were used as the control group.The levels of abnormal glycosylation of serum IgA1,total serum IgA1,serum superoxide dismutase(SOD),glutathione peroxidase(GSH-PX),malondialdehyde(MDA)and advanced oxidation protein product(AOPPs)were measured and compared in the three groups,and their correlations were analyzed.【Results】The serum IgA1 and abnormal glycosylation levels of IgA1 in the control group were lower than those in both HSP group and HSPN group,while the HSP group levels were lower than those of the HSPN group;the differences were statistically significant(P<0.05).The levels of SOD and GSH-PX in the control group were higher than those in the HSP group and the HSPN group;and the levels in the HSP group were higher than those in the HSPN group.The levels of MDA and AOPPs in the control group were lower than those in the HSP group and the HSPN group;and levels of the HSP group were lower than those of the HSPN group(P<0.05).Spearman analysis showed that IgA1 and the abnormal glycosylation of IgA1 were negatively correlated with SOD and GSH-PX(P<0.05),but positively correlated with MDA and AOPPs(P<0.05).【Conclusion】The levels of IgA1 and abnormal glycosylation of serum IgA1 in children with HSP are high,which are significant correlation with oxidative stress.

关 键 词：紫癜 过敏性/病理学 氧化性应激 

分 类 号：R725.546[医药卫生—儿科]