维生素D与代谢性炎症的研究进展  

Research progress of the relationship between vitamin D and metabolic inflammation

作　　者：高玲 袁天[3] 陈代娣 尹琳洁 陈业史 阳敏 童瑶 尹凯 桂庆军 GAO Ling;YUAN Tian;CHEN Dai-Di;YIN Lin-Jie;CHEN Ye-Shi;YANG Min;TONG Yao;YIN Kai;GUI Qing-Jun(Research Lab of Translational Medicine,Hengyang Medical school,University of South China,Hengyang 421001,China;Department of Cardiology,The First Affiliated Hospital of University of South China,Hengyang 421001,China;School of Transportation,Wuhan University of Techonology,Wuhan 430063,China;Public Sanitation College,University of South China,Hengyang 421001,China;School of Nursing,University of South China,Hengyang 421001,China;Clinical Medicine Department,Hengyang Medical school,University of South China,Hengyang 421001,China)

机构地区：[1]南华大学衡阳医学院转化医学研究室,衡阳421000 [2]南华大学附属第一医院心血管内科,衡阳421000 [3]武汉理工大学交通学院,武汉430063 [4]南华大学公共卫生学院,衡阳421000 [5]南华大学护理学院,衡阳421000 [6]南华大学衡阳医学院临床医学系,衡阳421000

出　　处：《生命科学》2019年第10期1060-1068,共9页Chinese Bulletin of Life Sciences

基　　金：湖南省自然科学基金项目(2018JJ2341);南华大学大学生研究性学习和创新性实验计划项目(2018-118)

摘　　要：维生素D(vitamin D,VitD)是一类固醇类衍生物,活性维生素D通过与维生素D受体(VDR)结合发挥多种生物学功能,除了与骨骼的生长发育相关之外,其对脂肪、肝脏及肾脏等多种组织器官的功能具有重要的调节作用。肥胖诱导的代谢性炎症与心血管疾病、糖尿病、代谢综合征等疾病密切相关,然而,维生素D与肥胖引发的代谢性炎症是否有直接的联系尚不明确。为此,该文对维生素D与代谢性炎症之间的关系作综述,以便揭示维生素D在代谢性炎症防治中的作用。Vitamin D(VitD)is a steroid derivative.Activated vitamin D exerts various biological functions by binding to vitamin D receptor(VDR).In addition to being associated with bone growth and development,it has an important regulatory effect on the functions of various tissues and organs such as fat,liver and kidney.Obesityinduced metabolic inflammation is closely related to diseases such as cardiovascular diseases,diabetes,and metabolic syndrome.However,it is not clear whether vitamin D is directly related to the metabolic inflammation caused by obesity.Therefore,this article reviews the relationship between vitamin D and metabolic inflammation,which may be able to reveal the role of vitamin D in the prevention and treatment of metabolic inflammation.

关 键 词：维生素D 肥胖 代谢性炎症 

分 类 号：Q565[生物学—生物化学]