一种植物复合提取物的抗炎止痒功效研究  

Study of anti-inflammatory efficacy of a herb composite extract

作　　者：卢伊娜 LU Yi-na(Shanghai JAKA Biotech Co. Ltd., Shanghai 200241, China)

机构地区：[1]上海珈凯生物科技有限公司

出　　处：《日用化学工业》2019年第11期737-741,共5页China Surfactant Detergent & Cosmetics

摘　　要：以蔓荆果﹑龙胆﹑何首乌根组成的植物复合提取物(VGP)为研究对象,通过多种方法对其抗炎止痒的功效进行研究。结果显示,在糠秕马拉色菌和过氧化氢(H2O2)诱导的角质形成细胞和单核细胞炎症模型上,VGP在质量分数为0.01%~0.125%的范围下能剂量依赖性地抑制白介素6(IL-6)﹑前列腺素E2(PGE-2)、单核细胞趋化蛋白1(MCP-1)和白介素1β(IL-1β)的表达。高浓度H2O2造成的人体皮肤损伤模型上,质量分数为0.5%和2%的VGP也能降低红斑及水泡的形成,缓解皮肤刺痛感及痒感。VGP作为一种天然来源的具有抗炎止痒功效的活性原料,可应用于头皮护理及皮肤护理领域。A herb composite extract VGP which consisted of Vitex trifolia fruit,Gentiana scabra,and Polygonum multiflorum root was prepared and its anti-inflammatory effect was studied by several methods.The results showed that on the model of NHEK and THP1 cell inflammation induced by Malassezia furfur and H2O2,VGP could inhibit the expressions of interleukin 6(IL-6),prostaglandin E2(PGE-2),monocyte chemoattractant protein 1(MCP-1)and interleukin 1β(IL-1β)in a dosage-dependent manner in the concentration range of 0.01%-0.125%.In the human skin injury model caused by high concentration of H2O2,VGP at the concentrations of 0.5%and 2%could reduce the formation of erythema and blisters and relieve pruritus.Therefore,as a natural active ingredient VGP could play a role in scalp care and skin care by targeting inflammation.

关 键 词：化妆品添加剂 植物复合提取物 抗炎止痒 头皮护理 

分 类 号：TQ658[化学工程—精细化工]