CD4^+新亚群Th9细胞与常见自身免疫病相关性的研究进展  

Research progress on correlation between CD4^+ new subsets of Th9 cells and common autoimmune diseases

作　　者：张会宁 王嘉军 ZHANG Huining;WANG Jiajun(Department of Nurse,An-Ning Sub-Hospital in 940th Hospital in Joint Logistic Support Force of the People's Liberation Army of China,Gansu Province,Lanzhou 730070,China;Teaching and Research Section of Medical Immunology,School of Medicine,Hubei Minzu University,Hubei Province,Enshi 445000,China)

机构地区：[1]解放军联勤保障部队第940医院安宁分院护理部,甘肃兰州730070 [2]湖北民族大学医学部医学免疫学教研室,湖北恩施445000

出　　处：《中国医药导报》2019年第28期48-51,共4页China Medical Herald

基　　金：国家自然科学基金资助项目（81760289）

摘　　要：Th9细胞是CD4+T细胞新发现的分化细胞亚群,该细胞通过分泌白细胞介素-9(IL-9)参与机体的免疫应答。在类风湿关节炎、系统性红斑狼疮等自身免疫病患者血液和组织中Th9细胞比例和IL-9的含量会产生较大变化,表明其与自身免疫病的发生发展有着密切关系。本文就近几年Th9细胞与常见自身免疫病相关性研究进展进行综述。Th9 cells are a newly discovered subset of differentiated CD4^+T cells that participate in the body′s immune response by secreting interleukin-9(IL-9).In patients with autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus,the proportion of Th9 cells and the content of IL-9 in the blood and tissues will change greatly,indicating that it is closely related to the occurrence and development of autoimmune diseases.This paper reviews the research progress on the correlation between Th9 cells and common autoimmune diseases in recent years.

关 键 词：TH9细胞 自身免疫病 类风湿关节炎 系统性红斑狼疮 白细胞介素-9 

分 类 号：R392.12[医药卫生—免疫学]