基于肠道碱性磷酸酶相关信号通路探讨针灸维持肠道菌群-免疫稳定作用的机制  

Based on intestinal alkaline phosphatase signaling pathway to discuss the mechanism of acupuncture maintaining intestinal flora-immune stability

作　　者：毛文姣 张红梅[2] MAO Wenjiao;ZHANG Hongmei(Department of Acupuncture,the Second Hospital of Nanjing,Jiangsu Province,Nanjing 210003,China;Department of Clinical Testing Center,the Second Hospital of Nanjing,Jiangsu Province,Nanjing 210003,China)

机构地区：[1]南京市第二医院针灸科,江苏南京210003 [2]南京市第二医院临床检测中心,江苏南京210003

出　　处：《中国医药导报》2019年第28期126-129,137,共4页China Medical Herald

基　　金：国家自然科学基金资助项目（81300323）

摘　　要：肠道微生物群的改变被认为肠易激综合征(IBS)发病机制的病因。肠道菌群-免疫失调导致肠道微环境的改变,诱发肠道的低度炎症。肠道碱性磷酸酶(IAP)通常能保护宿主免受肠道炎症和主要在结肠内的组织损伤,是维持肠道内环境稳定所必需的重要黏膜防御因子,被认为是肠道微生物群组成的潜在调节器。基于此,IAP相关通路可能是阐明针刺对肠道菌群-免疫稳定作用分子生物学机制的新切入点,促进对从脾论治与调控肠道菌群关系的认识,丰富中医从脾论治的科学内涵。The alteration of intestinal microflora is considered to be the cause of the pathogenesis of Irritable bowel syndrome(IBS).Intestinal flora-immune disorders lead to changes in the intestinal microenvironment,which induce low-grade inflammation of the intestines.Intestinal alkaline phosphatase(IAP)considered as a potential regulator of intestinal microflora,protects the host from intestinal inflammation and tissue damage mainly in the colon,while is an important mucosal defense factor necessary to maintain the stability of the intestinal environment.Based on the above poinits,IAP-related pathway may be a new entry point to elucidate the molecular biological mechanism of acupuncture on intestinal flora-immune stability,to promote the understanding of the relationship between treatment from spleen and regulation of intestinal flora,and to enrich the scientific connotation of treatment from spleen in Chinese medicine.

关 键 词：肠易激综合征 肠道微生物 肠道碱性磷酸酶 肠道菌群-免疫失调 

分 类 号：R246.1[医药卫生—针灸推拿学]