天芪降糖胶囊治疗糖尿病前期的Meta分析  

Meta-analysis of Tianqi Jiangtang Capsules in the treatment of prediabetes

作　　者：孙璐[1] 唐咸玉[1] 刘娜 SUN Lu;TANG Xianyu;LIU Na(Department of Endocrinology,Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangdong Province,Guangzhou 510120,China;General Three Department,Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangdong Province,Guangzhou 510120,China)

机构地区：[1]广东省中医院内分泌科,广东广州510120 [2]广东省中医院综合三科,广东广州510120

出　　处：《中国医药导报》2019年第28期138-141,146,共5页China Medical Herald

基　　金：广东省中医药局资助项目（20141133）

摘　　要：目的系统评价天芪降糖胶囊对糖尿病前期患者的糖尿病转化率、血糖、血脂、体重指数的影响。方法计算机检索公认的中英文数据库,纳入天芪降糖胶囊治疗糖尿病前期的随机对照试验,检索时限为1970~2018年12月。经过文献筛选、资料提取、偏倚风险和证据质量评价后,采用RevMan 5.3进行Meta分析。结果纳入7个研究,1061例患者。Meta分析结果显示,天芪降糖胶囊组的糖尿病转化率[OR=0.43,95%CI(0.32,0.58),P<0.00001]、空腹血糖[MD=-0.32,95%CI(-0.49,-0.16),P<0.0001]、餐后2 h血糖[MD=-1.24,95%CI(-1.86,-0.61),P=0.0001]均低于对照组。结论天芪降糖胶囊能延缓糖尿病前期人群进展为糖尿病,但仍需大量、高质量的研究证实。Objective To systematically evaluate the effects of Tianqi Jiangtang Capsules on diabetic conversion rate,blood sugar,blood lipid and body mass index in pre-diabetic patients.Methods Computerized Chinese and English databases were retrieved and included in the randomized controlled trial of Tianqi Jiangtang Capsules in the treatment of prediabetes.The retrieval time was 1970-2018 years in December.After literature screening,data extraction,bias risk and evidence quality evaluation,RevMan 5.3 was used for Meta-analysis.Results Included in 7 studies,1061 patients.Meta-analysis showed that diabetic conversion rate[OR=0.43,95%CI(0.32,0.58),P<0.00001],fasting blood sugar[MD=-0.32,95%CI(-0.49,-0.16),P<0.0001],postprandial blood sugar[MD=-1.24,95%CI(-1.86,-0.61),P=0.0001]in Tianqi Jiangtang Capsules group were lower than those in control group.Conclusion Tianqi Jiangtang Capsules can delay the progression of pre-diabetes to diabetes,but a large number of high-quality studies are needed to confirm it.

关 键 词：糖尿病前期 天芪降糖胶囊 随机对照试验 META分析 

分 类 号：R587.1[医药卫生—内分泌]