留置宫内节育器与异位妊娠发生关系的Meta分析  

Relationship between intrauterine device and incidence of ectopic pregnancy:a Meta-analysis

作　　者：袁烁[1] 沈秋娴 卢如玲[1] 邓高丕[1] YUAN Shuo;SHEN Qiuxian;LU Ruling;DENG Gaopi(Department of Gynecology,the First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangdong Province,Guangzhou510405,China;the First Clinical Medical College,Guangzhou University of Chinese Medicine,Guangdong Province,Guangzhou510120,China)

机构地区：[1]广州中医药大学第一附属医院妇科国家华南区中医妇科区域诊疗中心,广东广州510405 [2]广州中医药大学第一临床医学院,广东广州510405

出　　处：《中国医药导报》2019年第30期93-96,共4页China Medical Herald

基　　金：国家自然科学基金资助项目（81804134）;广东省科技创新项目（基础与应用基础方向）（2018A030313469）;广东省医疗卫生健康事业发展专项（传承发展中医药事业—邓高丕广东省名中医传承工作室）（粤中医办函[2019]5号）

摘　　要：目的通过荟萃分析探究留置宫内节育器(IUD)与异位妊娠发生的关系,为防治异位妊娠提供循证医学证据。方法检索时间为建库至2019年5月10日,检索EMbase、PubMed、The Cochrane Library、CNKI、WanFang、VIP数据库关于留置IUD与异位妊娠发生关系的随机病例对照研究,以异位妊娠的妇女为病例组,正常妊娠妇女为对照组,记录两组留置宫内节育器的例数。由3名研究者独立对符合纳排标准的文献进行数据提取,采用NOS评分进行文献质量评价,亚组分析或敏感性分析探讨异质性的来源。结果共纳入19项病例对照研究,其中病例组2736例,对照组3863例。分析结果提示,病例组发生异位妊娠的可能性是对照组的3.11倍,差异有高度统计学意义(P<0.00001)。结论IUD是异位妊娠发生的危险因素之一。Objective To explore the relationship between intrauterine device(IUD)and ectopic pregnancy using a meta-analysis and provide evidence for prevention and treatment of ectopic pregnancy.Methods From the database built to May 10,2019,Embase,PudMed,the Cochrane Library,China National Knowledge Infrastructure,WanFang Database,VIP Database were searched for randomized case-control studies on the relationship between IUD retention and ectopic pregnancy.Women with ectopic pregnancy were selected as the case group and women with normal pregnancy were selected as the control group.The number of patients with IUD in both groups were recorded.Data were extracted with 3 researchers independently from literatures that met the inclusion criteria.NOS score was used for literature quality evaluation.The sources of heterogeneity were explored with subgroup analysis or sensitivity analysis.Results A total of 19 case-control studies were included.There were 2736 cases in the case group and 3863 cases in the control group.The results showed that the probability of ectopic pregnancy with the case group was 3.11 times higher than that in the control group,the difference is highly statistically significant(P<0.00001).Conclusion IUD is one of the risk factors of ectopic pregnancy.

关 键 词：宫内节育器 异位妊娠 危险因素 META分析 

分 类 号：R714.22[医药卫生—妇产科学]