毓麟珠合桂枝茯苓丸加味治疗多囊卵巢综合征排卵障碍性不孕临床研究  

Clinical Study on Modified Yulin Zhu Combined with Guizhi Fuling Pills for Infertility due to Ovulation Disorders Caused by Polycystic Ovary Syndrome

作　　者：楼雪莉 陈瑜 LOU Xueli;CHEN Yu

机构地区：[1]诸暨市第三人民医院

出　　处：《新中医》2019年第11期43-47,共5页New Chinese Medicine

摘　　要：目的:观察毓麟珠合桂枝茯苓丸加味治疗多囊卵巢综合征(PCOS)排卵障碍性不孕的临床疗效及对患者性激素、瘦素、胰岛素样生长因子-1 (IGF-1)、转化生长因子-β1 (TGF-β1)水平的影响。方法:选取74例PCOS排卵障碍性不孕患者为研究对象,随机分为对照组和观察组各37例。对照组口服枸橼酸氯米芬胶囊治疗,观察组在对照组基础上给予毓麟珠合桂枝茯苓丸加味内服,2组均连续用药3个月经周期。统计排卵率、妊娠率,对比2组性激素水平、成熟卵泡数、优势卵泡直径、子宫内膜厚度及子宫内膜形态分型情况,检测瘦素、IGF-1、TGF-β1水平。结果:治疗后,2组排卵率比较,差异无统计学意义(P>0.05)。观察组妊娠率高于对照组,差异有统计学意义(P<0.05)。治疗后,2组雌激素(E2)、孕酮(P)、卵泡刺激素(FSH)水平均较治疗前升高(P<0.05),黄体生成素(LH)水平均较治疗前降低(P<0.05);组间比较,观察组各项性激素水平升高或降低幅度更明显(P<0.05)。治疗后,观察组成熟卵泡数多于对照组(P<0.05),优势卵泡直径大于对照组(P<0.05),子宫内膜厚于对照组(P<0.05)。治疗后,2组A型子宫内膜数均较治疗前增加(P<0.05);观察组A型子宫内膜数多于对照组(P<0.05)。治疗后,2组瘦素、IGF-1、TGF-β1水平均较治疗前降低(P<0.05);观察组上述3项指标水平均比对照组降低更明显(P<0.05)。结论:毓麟珠合桂枝茯苓丸加味有助于改善PCOS排卵障碍性不孕患者的性激素水平,促进排卵,提高妊娠率,作用机制可能与下调血清中瘦素、IGF-1、TGF-β1水平有关,值得临床推广运用。Objective:To observe the clinical effect of the modified use of Yulin zhu combined with Guizhi Fuling pills for infertility due to ovulation disorders caused by polycystic ovary syndrome(PCOS),and its effect on the levels of sex hormones and leptin,insulin-like growth factor-1(IGF-1) as well as transforming growth factor-β1(TGF-β1).Methods:A total of 74 cases of patients with infertility due to ovulation disorders caused by PCOS were selected as the study subjects and were randomly divided into the control group and the observation group,37 cases in each group.The control group was given oral administration of clomifene citrate capsules,and the observation group was additionally treated with oral administration of modified Yulin zhu and Guizhi Fuling pills based on the treatment of the control group.Both groups were administrated for three menstrual cycles.The ovulation rates and the pregnancy rates were counted.The levels of sex hormones,the number of mature follicles,the diameter of dominant follicles,the endometrial thickness and the classification of endometrial morphology in the two groups were compared.The levels of leptin,IGF-1 and TGF-β1 were detected.Results:After treatment,there was no significant difference being found in the comparison of the ovulation rate in the two group(P>0.05).The pregnancy rate in the observation group was higher than that in the control group,the difference being significant(P<0.05).After treatment,the levels of estrogen(E2),progesterone(P) and follicle stimulating hormone(FSH) in the two groups were increased when compared with those before treatment,and the levels of luteinizing hormone(LH) were decreased when compared with those before treatment(P<0.05);the increase or decrease of the levels of each sex hormone in the observation group was more significant than that in the control group(P<0.05).After treatment,the number of mature follicles in the observation group was more than that in the control group;the diameter of dominant follicles was larger than that in the contr

关 键 词：多囊卵巢综合征(PCOS) 排卵障碍性不孕 毓麟珠 桂枝茯苓丸 性激素 瘦素 胰岛素样生长因子-1(IGF-1) 转化生长因子-β1 (TGF-β1) 

分 类 号：R711.6[医药卫生—妇产科学]