通腑活血法治疗脓毒症肠功能障碍临床研究  

Clinical Study on Fu-organ-unblocking and Blood-activating Method for Sepsis Com-plicated with Intestinal Dysfunction

作　　者：朱德才 郭权来 邓勤勤 ZHU Decai;GUO Quanlai;DENG Qinqin

机构地区：[1]广州中医药大学第二临床医学院

出　　处：《新中医》2019年第11期119-121,共3页New Chinese Medicine

基　　金：广东省中医药局科研项目(20162068)

摘　　要：目的:观察通腑活血法治疗脓毒症肠功能障碍患者的临床疗效。方法:选取60例脓毒症合并肠功能障碍患者,按随机数字表法分为对照组和治疗组各30例。对照组给予西医标准治疗,治疗组在对照组基础上给予桃核承气汤口服。治疗前后统计分析2组一般情况、肠功能障碍评分、D-乳酸等指标。结果:治疗前,2组APACHEⅡ评分、D乳酸、肠功能评分、白细胞计数(WBC)、降钙素原、血清二胺氧化酶(DAO)水平比较,差异均无统计学意义(P>0.05)。治疗后,2组APACHEⅡ评分、D乳酸、肠功能评分、WBC、降钙素原、血清DAO水平均较治疗前降低,且治疗组APACHEⅡ评分、D乳酸、肠功能评分、血清DAO水平低于对照组,差异均有统计学意义(P<0.05)。结论:通腑活血法可降低脓毒症患者肠功能评分及D乳酸水平,保护肠黏膜屏障,促进血液循环,从而改善患者肠功能。Objective:To observe the clinical effect of fu-unblocking and blood-activating method for patients with sepsis complicated with intestinal dysfunction.Methods:A total of 60 patients with sepsis complicated with intestinal dysfunction were selected and divided into the control group and the treatment group according to the random number table method,30 cases in each group.The control group was treated with standard western medicine,and the treatment group was additionally treated with Taohe Chengqi Tang orally based on the treatment of the control group.Before and after treatment,the general situation,score of intestinal dysfunction,D-lactic acid and other indicators of the two groups were statistically analyzed.Results:Before treatment,there was no significant difference being found in the comparison of the score of APACHE Ⅱ,D-lactic acid,score of intestinal function,the WBC,procalcitonin and the level of serum DAO between the two groups(P>0.05).After treatment,the above scores and levels in the two groups were decreased when compared with those before treatment,and those in the treatment group were lower than those in the control group,differences being significant(P<0.05).Conclusion:The fu-organ-unblocking and blood-activating method can reduce the score of intestinal function and the level of D-lactic acid in patients with sepsis,protect the intestinal mucosal barrier,promote blood circulation,and thus improve the intestinal dysfunction.

关 键 词：脓毒症 肠功能障碍 通腑活血法 桃核承气汤 APACHEⅡ评分 D乳酸 肠功能评分 

分 类 号：R459.7[医药卫生—急诊医学]