安胎止血方联合西药治疗不明原因性复发性流产临床研究  

Clinical Study on Antai Zhixue Prescription Combined with Western Medicine for Unexplained Recurrent Spontaneous Abortion

作　　者：冯延红[1] FENG Yanhong

机构地区：[1]南阳市中心医院产科

出　　处：《新中医》2019年第11期160-163,共4页New Chinese Medicine

摘　　要：目的:探讨安胎止血方联合西药治疗不明原因性复发性流产(URSA)的疗效。方法:选取102例URSA患者,按随机数字表法分为观察组和对照组各51例。对照组予以常规西药治疗,观察组在对照组基础上予以安胎止血方治疗。比较2组患者妊娠结局和临床疗效,观察治疗前后中医证候积分、血清胎盘生长因子(PLGF)、血管生成素-2 (Ang-2)、纤溶酶原激活物抑制物-1 (PAI-1)等指标变化情况。结果:观察组妊娠成功率为88.24%,显著高于对照组70.59%(P<0.05)。观察组总有效率为86.27%,显著高于对照组66.67%(P<0.05)。治疗前,2组中医证候积分比较,差异无统计学意义(P>0.05)。治疗后,2组中医证候积分均较治疗前降低,且观察组中医证候积分低于对照组,差异均有统计学意义(P<0.05)。治疗前,2组血清PLGF、Ang-2、PAI-1水平比较,差异无统计学意义(P>0.05)。再次妊娠后,2组血清PLGF、Ang-2水平均较治疗前升高,PAI-1水平较治疗前降低;且观察组血清PLGF、Ang-2水平高于对照组,PAI-1水平低于对照组;差异均有统计学意义(P<0.05)。结论:安胎止血方联合西药对URSA有较好的疗效,可明显改善临床症状,促进血管生成,有利于胚胎着床和妊娠,进而提高妊娠成功率。Objective:To discuss the curative effect of Antai Zhixue prescription combined with western medicine for unexplained recurrent spontaneous abortion(URSA).Methods:A total of 102 cases of URSA patients were divided into the observation group and the control group according to the random number table method,51 cases in each group.The control group was treated with routine western medicine,and the observation group was additionally treated with Antai Zhixue prescription based on the treatment of the control group.The differences of pregnant outcomes and clinical effect in the two groups were compared.The changes of Chinese medicine syndrome scores,placental growth factors(PLGF),angiopoietin-2(Ang-2) and plasminogen activator inhibitor-1(PAI-1) in serum before and after treatment were observed.Results:The pregnancy success rate was 88.24% in the observation group,significantly higher than that of 70.59% in the control group(P<0.05).The total effective rate was 86.27% in the observation group,significantly higher than that of 66.67% in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of Chinese medicine syndrome scores in the two groups(P>0.05).After treatment,Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment,and the scores in the observation group was lower than that in the control group,differences being significant(P<0.05).Before treatment,compared the levels of PLGF,Ang-2 and PAI-1 in serum in the two groups,there was no significance in the difference(P>0.05).During the subsequent pregnancy,the levels of PLGF and Ang-2 in serum in the two groups were increased when compared with those before treatment,and the levels of PAI-1 were decreased when compared with those before treatment;the levels of PLGF and Ang-2 in serum in the observation group were higher than those in the control group,and the level of PAI-1 was lower than that in the control group;differences being significant(P<0.05).Conclusion:Th

关 键 词：不明原因性复发性流产(URSA) 安胎止血方 胎盘生长因子(PLGF) 血管生成素-2 (Ang-2) 纤溶酶原激活物抑制物-1 (PAI-1) 

分 类 号：R714.21[医药卫生—妇产科学]