山豆根中毒致双侧小脑齿状核病变1例  

A Case of Bilateral Dentate Nucleus Lesions Caused by Radix et Rhizoma Sophorae Tonkinensis Poisoning

作　　者：赵彩云 张震中[2] ZHAO Caiyun;ZHANG Zhenzhong

机构地区：[1]浙江中医药大学第二临床医学院,浙江杭州310053 [2]浙江省立同德医院神经内科,浙江杭州310012

出　　处：《新中医》2019年第11期344-346,共3页New Chinese Medicine

摘　　要：山豆根是中医常用中药,有清热解毒、利咽喉、散肿止痛等功效。但超剂量使用会引起中毒,其毒性主要累及神经系统、消化系统和呼吸系统。山豆根中毒对中枢神经系统的毒性主要为基底节对称性的损害(豆状核为主要受累部位),而其对于小脑损害的表现报道较少。笔者对浙江中医药大学第二临床医学院就诊的1例仅波及双侧小脑齿状核的患者的临床特点进行分析报道。该患者主要表现为口齿不清和步行不稳,神经查体可见构音障碍及共济失调的阳性体征。通过对该病例特点的总结报道,以期为临床表现不典型的山豆根中毒患者提供诊断参考。Radix et Rhizoma Sophorae Tonkinensis is a commonly used Chinese medicine,with the effect of clearing heat and detoxicating,soothing the throat as well as dispersing swelling and relieving pain.However,overdose can cause poisoning,which mainly affects the nervous system,digestive system and respiratory system.The poisoning of Radix et Rhizoma Sophorae Tonkinensis to the central nervous system is mainly symmetrical lesions of the basal ganglia(the lentiform nucleus is the main site of involvement),but the manifestations of cerebellar lesions are rarely reported.The clinical characteristics of the only patient with involvement of bilateral dentate nucleus lesions in the second clinical medical college of zhejiang university of Chinese medicine were analyzed and reported by the author.The main manifestations of the patient were slurred speech and gait instability,and positive signs of dysarthria and ataxia could be seen in neurological examination.Through summarizing and reporting the characteristics of this case,we hope to provide diagnostic reference for patients with untypical clinical manifestations of Radix et Rhizoma Sophorae Tonkinensis poisoning.

关 键 词：山豆根 中毒 小脑齿状核 病例分析 

分 类 号：R249.2[医药卫生—中医临床基础]