奥氮平对精神障碍患者肝功能、血脂、血糖及泌乳素的影响因素研究  

Effect of olanzapine on liver function,blood lipid,blood glucose and prolactin of patients with mental disorders

作　　者：李方捷[1] 李红[1] 马燕[1] 申书娟 毛叶萌[1] LI Fang-jie;LI Hong;MA Yan;SHEN Shu-juan;MAO Ye-meng(Department of Pharmacy,Shanghai Mental Health Center,Shanghai Jiaotong University,Shanghai 200030,China)

机构地区：[1]上海交通大学医学院附属精神卫生中心药剂科

出　　处：《实用药物与临床》2019年第11期1130-1133,共4页Practical Pharmacy and Clinical Remedies

基　　金：上海医院药学科研基金资助(2017-YY-02-05);上海交通大学医学院药学青年基金(JDYX2017QN020)

摘　　要：目的探讨奥氮平对精神障碍患者肝功能、血脂、血糖及泌乳素的影响。方法选取2018年1-12月使用奥氮平治疗引起肝功能异常的患者,比较治疗前后患者的奥氮平血药浓度、肝功能指标、血糖、血脂、泌乳素,分析奥氮平对精神障碍患者肝功能异常的影响因素。结果服用奥氮平后碱性磷酸酶的升高与年龄因素呈显著正相关(P<0.01)。总胆固醇升高与性别显著相关,三酰甘油升高与体重基数显著相关,泌乳素升高与性别、体重、精神障碍疾病诊断及奥氮平血药浓度均显著相关(P<0.01)。血糖值的升高与年龄有关。结论精神障碍患者在使用奥氮平时,不仅要考虑药物疗效,还需观察不良反应,监测相关肝功能、血糖、血脂、泌乳素指标和药物血药浓度,保证临床用药安全有效。Objective To investigate the effects of olanzapine on liver function,blood lipids,blood glucose and prolactin in patients with mental disorders.Methods Patients with liver dysfunction caused by olanzapine treatment from January to December in 2018 were selected to compare the changes of olanzapine's blood concentration,liver function indexes,blood glucose,lipid and prolactin before and after treatment;analyze the influencing factors of olanzapine on liver dysfunction in patients with mental disorders.Results The increase in alkaline phosphatase was positively correlated with age(P<0.01).The increase in total cholesterol was significantly correlated with gender,the increase in triglyceride was significantly correlated with body weight base,and the increase in prolactin was significantly correlated with gender,body weight,the diagnosis of mental disorders and the blood concentration of olanzapine(P<0.01).Elevated blood glucose levels are associated with age.Conclusion When patients with mental disorders use olanzapine,doctors should not only consider the efficacy of the drug,but also observe the adverse reactions and monitor the related indicators of liver function,blood glucose,blood lipid,prolactin and drug plasma concentration,so as to ensure the safety and effectiveness of clinical medication.

关 键 词：奥氮平 精神障碍 肝功能 血脂 血糖 泌乳素 

分 类 号：R74[医药卫生—神经病学与精神病学]