疏肝养血通络方联合米非司酮对子宫内膜异位症痛经患者疼痛程度及血清 PGE2、PGF2α、NGF水平的影响  

Effect of Shugan Yangxue Tongluo decoction combined with mifepristone on pain degree and serum PGE2, PGF2α and NGF Levels in patients with endometriosis and dysmenorrhea

作　　者：张微 卢建军[1] ZHANG Wei;LU Jianjun(Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010059,Inner Mongolia,China)

机构地区：[1]内蒙古医科大学附属医院

出　　处：《现代中西医结合杂志》2019年第32期3576-3580,共5页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的观察疏肝养血通络方联合米非司酮对子宫内膜异位症痛经患者疼痛程度及血清前列腺素E2(PGE2)、前列腺素F 2α(PGF 2α)、神经生长因子(NGF)水平的影响。方法将104例子宫内膜异位症痛经患者随机分为2组,对照组52例给予米非司酮口服治疗,观察组52例在对照组基础上给予疏肝养血通络方治疗,连续治疗3个月经周期,比较2组治疗后单项症状(经期或行经前后小腹胀痛、乳房胀痛、胸闷不适、经行不畅)、疼痛状况[COX痛经症状评分量表(CMSS)评分、视觉模拟评分(VAS)]及实验室检查指标(PGE2、PGF 2α、NGF)改善情况,统计2组临床总有效率及治疗期间不良反应发生率。结果2组治疗后经期或行经前后小腹胀痛、乳房胀痛、胸闷不适、经行不畅积分和COX评分、VAS评分均较治疗前明显降低(P均<0.05),且观察组以上症状积分均明显低于对照组(P均<0.05);2组治疗后血清PGE2、PGF 2α、NGF水平均较治疗前明显降低(P均<0.05),且观察组血清PGE2、PGF 2α、NGF水平均明显低于对照组(P均<0.05);观察组总有效率显著高于对照组(P<0.05);观察组不良反应发生率为7.7%(4/52),对照组不良反应发生率为11.5%(6/52),2组不良反应发生率比较差异无统计学意义(P>0.05)。结论疏肝养血通络方联合米非司酮能够抑制子宫内膜异位症痛经患者血清PGE2、PGF 2α、NGF表达,改善患者痛经等症状,安全性高,疗效确切。Objective It is to observe the effect of Shugan Yangxue Tongluo decoction combined with mifepristone on pain degree and levels of serum prostaglandin E2(PGE2),prostaglandin F 2α(PGF 2α)and nerve growth factor(NGF)in patients with dysmenorrhea due to endometriosis.Methods 104 patients with dysmenorrhea due to endometriosis were randomly divided into 2 groups.52 patients in the control group were treated with mifepristone orally.52 patients in the observation group were given Shugan Yangxue Tongluo decoction on the basis of the control group.Both groups were treated for 3 menstrual cycles.The improvements of single symptom(abdominal pain in menstruation or before menstruation,breast distending pain,chest discomfort,menstrual disorder),pain status[COX dysmenorrhea symptom score scale(CMSS)score,vision simulated score(VAS)]and laboratory test indicators(PGE2,PGF 2α,NGF)after treatment were compared between the two groups,the total clinical effective rate and the incidence of adverse reactions during treatment were calculated and compared.Results After treatment,the scores of abdominal pain in menstruation or before menstruation,breast distending pain,chest discomfort,menstrual disorder,COX scores and VAS scores were significantly decreased compared with before treatment in the two groups(P<0.05),and the decrease in the observation group was more significant(P<0.05).The levels of serum PGE2,PGF 2αand NGF were significantly lower after treatment than those before treatment in the two groups(P<0.05),and the serum levels of PGE2,PGF 2αand NGF in the observation group were significantly lower than those in the control group(P<0.05).The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).The incidence of adverse reactions in the observation group was 7.7%(4/52),and that in the control group was 11.5%(6/52),there was no statistical significance between the two groups(P>0.05).Conclusion Shugan Yangxue Tongluo decoction combined with mifepristone can inhibit the e

关 键 词：子宫内膜异位症 痛经 疏肝养血通络方 米非司酮 前列腺素E2 前列腺素F 2α 神经生长因子 

分 类 号：R711.71[医药卫生—妇产科学]