孝感市丙型肝炎的流行病学调查分析  

Survey and analysis of epidemiology of hepatitis C in Xiaogan area

作　　者：杨叶子[1] 魏威[2] YANG Yezi;WEI Wei(Department of Clinical Laboratory,Jingzhou Municipal Central Hospital,Jingzhou,Hubei 434000,China;Central Laboratory,Xiaogan Municipal Central Hospital,Xiaogan,Hubei 432100,China)

机构地区：[1]湖北省荆州市中心医院检验科,湖北荆州434000 [2]湖北省孝感市中心医院中心实验室,湖北孝感432100

出　　处：《检验医学与临床》2019年第22期3301-3303,3307,共4页Laboratory Medicine and Clinic

摘　　要：目的分析湖北省孝感市丙型肝炎的流行特征。方法选取中国疾病预防控制信息系统湖北省孝感市2015-2017年报告的10840例丙型肝炎患者为研究对象,对其年龄、性别、职业、所属地区和发病时间等信息进行统计分析。之后随机选取部分患者(720例),询问其感染方式并对患者所感染的病毒基因亚型进行检测。结果2015-2017年孝感市丙型肝炎发病率逐年递增,年平均发病率为25.37/10万;性别方面,男性患者数是女性的1.16倍;年龄方面,随年龄增长发病率大致呈先升后降的趋势,50~<60岁年龄段患者的发病率高于其他年龄段(P<0.05);地区分布方面,患者主要集中在云梦县和孝南区,两地的发病率均高于其他地区(P<0.05);发病时间方面,各月的构成比较为均匀,季节差异无统计学意义(P>0.05);职业方面,构成比较高的前3位依次为农民(29.18%)、商业服务人员(20.56%)和离退休人员(18.10%)。共720例患者参与调查,结果显示在所有感染途径中有偿献血占比最高(80.51%);病毒基因亚型方面,以1b和2a为主,分别占85.77%和13.82%。结论孝感市丙型肝炎防控形势严峻,相关部门应加强防控措施,有效降低发病率。Objective To analyze the epidemiological characteristics of hepatitis C in Xiaogan area of Hubei Province.Methods A total of 10840 cases of hepatitis C reported in Xiaogan City of Hubei Province from China Disease Prevention and Control Information System during 2015-2017 were selected as the research subjects,and their age,sex,occupation,regional distribution and onset time of disease conducted the statistical analysis.Then partial patients(720 cases)were randomly selected for inquiring their infection mode,moreover the infected viral sub-genotypes were detected.Results The incidence rate of hepatitis C in Xiaogan City during 2015-2017 was increased year by year,with an average annual incidence rate of 25.37/100000;in the aspect of gender,the number of male cases was 1.16 times that of female;in the aspect of age,the incidence rate of the disease was increased first and then decreased with the age increase,and the incidence rate of 50-<60 years old was higher than that of other age groups(P<0.05).In the aspect of area distribution,the patients were mainly concentrated in Yunmeng County and Xiaonan District.The incidence rates of the two areas were all higher than those in the other areas(P<0.05);in the aspect of onset time of the disease,the constituent ratio in each month was more uniform and the seasonal difference had no statistical significance(P>0.05);in the aspect of profession,the top three places in the constituent ratio were in turn farmers(29.18%),business service personnel(20.56%)and retirees(18.10%).A total of 720 eligible patients participated in the trial.The results showed that paid blood donation was the highest route of transmission with the highest proportion(80.51%);in the aspect of viral sub-genotype,1b and 2a were predominant,accounting for 85.77%and 13.82%respectively.Conclusion The prevention and control situation of hepatitis C is serious,the relevant departments should strengthen the prevention and control measures to effectively reduce its incidence rate.

关 键 词：丙型肝炎 流行病学 基因亚型 疫情分析 

分 类 号：R512.63[医药卫生—内科学]