2型糖尿病患者血清成纤维细胞生长因子21水平与糖尿病肾脏疾病及糖尿病视网膜病变的相关性研究  被引量:16

Relationship between serum fibroblast growth factor 21 and diabetic kidney disease and retinopathy

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作  者:李林娟[1] 张梅[1] 李转霞[1] 韩秀平[1] 郑俊晨[2] LI Linjuan;ZHANG Mei;LI Zhuanxia(Department of General Medicine,Yan’an University Affiliated Hospital,Yan’an 716000,China)

机构地区:[1]延安大学附属医院综合内科,716000 [2]延安大学附属医院心脏血管中心,716000

出  处:《中国糖尿病杂志》2019年第11期812-815,共4页Chinese Journal of Diabetes

摘  要:目的探讨血清成纤维细胞生长因子21(FGF21)与DKD及DR的关系。方法选取2016年3月至2018年3月于延安大学附属医院综合内科就诊的T2DM患者227例,根据UACR及散瞳眼底照相结果分为单纯T2DM患者(T2DM组)160例、T2DM合并DKD患者(DKD组)33例及T2DM合并DR患者(DR组)34例。比较各组血清FGF21并分析其与DKD、DR的相关性。结果DKD、DR组血清FGF21高于T2DM组[(275. 44±62. 20)vs(334. 13±29. 28)vs(171. 50±24. 07)pg/ml,P<0. 05]。Pearson相关分析显示,血清FGF21与糖尿病病程、BMI、SBP、DBP、FPG、HbA1c、UACR及血β2微球蛋白呈正相关(r=0. 315、0. 141、0. 197、0. 527、0. 634、0. 502、0. 534、0. 224,P<0. 05)。多因素Logistic回归分析显示,血清FGF21是DKD的危险因素(OR 1. 21,95%CI 2. 09~4. 13,P<0. 01)。结论 DKD、DR患者血清FGF21上升;血清FGF21是DKD的危险因素。Objective To investigate the relationship between serum fibroblast growth factor 21(FGF21)level and diabetic kidney disease(DKD)and diabetic retinopathy(DR).MethodsFrom March 2016 to March 2018,227 patients with type 2 diabetes mellitus(T2DM)in Yan’an university affiliated hospital were enrolled in the study,including T2DM group(n=160),DKD group(n=33)and DR group(n=34). The serum FGF21 and other clinical data were collected and compared. The associations between the serum FGF21 levels and DKD and DR were analyzed.ResultsCompared with T2DM group,serum FGF21 was significantly increased in DKD group and DR group[(275. 44±62. 20)vs(334. 13±29. 28)vs(171. 50 ± 24. 07)pg/ml,P<0. 05]. Pearson correlation analysis showed that the duration of diabetes,BMI,SBP,DBP,FPG,HbA1c,UACR and β2 MG were positively correlated with FGF21(r=0. 315,0. 141,0. 197,0. 527,0. 634,0. 502,0. 534 and 0. 224,P<0. 05). Logistic regression analysis showed that serum FGF21 was associated with DKD(OR 1. 21,95%CI 2. 09~4. 13,P<0. 01).Conclusion Serum FGF21 levels are increased in patients with DKD and DR. Serum FGF21 may be a risk factor for DKD.

关 键 词:糖尿病 血清成纤维细胞生长因子21 糖尿病肾脏疾病 糖尿病视网膜病变 

分 类 号:R58[医药卫生—内分泌]

 

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