热敏灸联合中药治疗小儿难治性肾病综合征的减毒增效研究  

Study on The Attenuation and Efficacy of Heat-sensitive Moxibustion and Chinese Herbs in The Treatment of Children with Intractable Nephrotic Syndrome

作　　者：喻闽凤[1] 洪恩四[1] 赵纪生[1] 刘莎莎 朱卫娜[1] 占科[1] 余红英[1] 刘英[1] 曾思瑶 钟业敏 YU Min-feng;HONG En-si;ZHAO Ji-sheng;LIU Sha-sha;ZHU Wei-na;ZHAN Ke;YU Hong-ying;LIU Ying;ZENG Si-yao;ZHONG Ye-min(The Affiliated Hospital of Jiangxi University of Chinese Medicine,Nanchang 330006,China;No.4 Clinical College,Guangzhou University of Chinese Medicine,Guangdong Shenzhen 518000,China)

机构地区：[1]江西中医药大学附属医院,南昌330006 [2]广州中医药大学第四临床医学院,广东深圳518000

出　　处：《中国中医基础医学杂志》2019年第10期1409-1412,共4页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：江西省科技计划项目(20151BBG70128)-热敏灸合中药治疗小儿难治性肾病综合征的临床对比研究;深圳市三名工程(SZSM201812064)-深圳市引进高层次医学团队——南京中医药大学汪受传教授中医儿科学团队

摘　　要：目的:观察热敏灸联合中药治疗小儿难治性肾病疗效的研究。方法:65例患儿按随机数字表法分为观察组和对照组,对照组给予激素+环磷酰胺冲击治疗,观察组加用热敏灸和肾病方治疗,并比较总临床疗效、24h尿蛋白定量、血浆白蛋白(ALB)及总胆固醇(TC)水平,观察不良反应及复发率。结果:临床疗效方面,治疗6个月观察组缓解率高于对照组,治疗12个月观察组缓解率明显高于对照组。中医证候学方面,观察组也高于对照组;组内比较治疗后较治疗前各项均有显著改善。观察组差异有统计学意义,对照组仅24h尿蛋白定量及ALB差异有统计学意义。组间比较,观察组较对照组均有明显改善,在24h尿蛋白定量及ALB改善明显;不良反应方面,观察组低于对照组;对照组复发4例,治疗组无复发病例。结论:热敏灸联合中药治疗小儿难治性肾病综合征可明显提高其临床疗效,减少不良反应及复发。Objective:To observe the clinical efficacy of heat-sensitive moxibustion combined with traditional Chinese medicine in children with refractory nephrotic syndrome.Methods:Sixty-five patients were randomly divided into the observation group and the control group.The control group was treated with hormone+cyclophosphamide.The observation group was treated with heat-sensitive moxibustion and kidney disease on the basis of the control group.The total clinical efficacy,24h urinary protein,plasma albumin(ALB)and total cholesterol(TC)were compared,and the adverse reactions and recurrence rates were also compared between the two groups.Results:Compared with the control group,the remission rate was higher in the observation group than the control group after 6 months of treatment.After 12 months of treatment,the clinical remission rate was significantly higher in the observation group than in the control group.In TCM syndromes,the observation group was also higher than the control group;Within the group,there was a significant improvement after treatment compared with before treatment.The observation group was statistically significant.In the control group,only 24-hour urinary protein and ALB were statistically significant.Between groups,the observation group had significantly improved compared with the control group,and the urinary protein quantitation and ALB improvement at 24 h were significantly;The incidence of adverse reactions in the observation group was significantly lower than that the control group;During follow-up,4 patients in the control group relapsed and no recurrence occurred in the treatment group.Conclusion:Heat-sensitive moxibustion combined with traditional Chinese medicine treatment of children with refractory nephrotic syndrome can significantly improve its clinical efficacy and reduce its adverse reactions and recurrence.

关 键 词：热敏灸 难治性肾病综合征 疗效 

分 类 号：R692[医药卫生—泌尿科学]