Asymmetric Difluoromethylthiolation of Carbon Nucleophiles with Optically Pure Difluoromethylthiolating Reagents Derived from Camphorsultam  

作　　者：He Zhang Xiaolong Wan Qilong Shen 

机构地区：[1]Key Laboratory of Organofluorine Chemistry,Center for Excellence in Molecular Synthesis,Shanghai Institute of Organic Chemistry,University of Chinese Academy of Sciences,Chinese Academy of Sciences,345 Lingling Lu,Shanghai 200032,China

出　　处：《Chinese Journal of Chemistry》2019年第10期1041-1050,共10页中国化学（英文版）

基　　金：The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China(Nos.21625206,21632009,21421002,21572258)。

摘　　要：The invention of a family of optically pure electrophilic difluoromethylthiolating reagents 9a-c based on the camphorsultam skeleton was described.These reagents reacted with a variety of soft carbon nucleophiles such as oxazolone,oxindole,benzolactone and β-ketoester in good to excellent enantioselectivities.

关 键 词：THIOL SKELETON REAGENT 

分 类 号：O62[理学—有机化学]