幼虫巨大致死基因1(Lgl1)对小鼠嗅球神经发育的影响  

Effect of Lgl1 on the development of olfactory bulb in mice

作　　者：李珍祖[1] 王可[2] LI Zhenzu;WANG Ke(Department of Bio-engineering,Shandong Polytechnic,Jinan 250014,China;Institute of Animal Science and Veterinary Medicine/Shandong Province Key Laboratory of Disease Prevention and Treatment and Breeding of Live Stock and Poultry,Shandong Academy of Agricultural Sciences,Jinan 250100,China)

机构地区：[1]山东职业学院生物工程系,山东济南250014 [2]山东省农业科学院畜牧兽医研究所/山东省畜禽疫病防治与繁育重点试验室,山东济南250100

出　　处：《畜牧与兽医》2019年第11期143-146,共4页Animal Husbandry & Veterinary Medicine

基　　金：山东省高校科研计划项目(J18KA149)

摘　　要：神经元迁移是一个高度完整和程序化的过程,伴随着神经元的分化、极性化和定向,这一过程在正常生理发育和异常的病理发生过程中起重要作用。Lgl1作为肿瘤抑制因子发现于线虫中,但随后发现它在细胞的增殖、分化、组织和极性确定中同样起重要作用。本文综述了Lgl1在嗅球发育过程中对各层特征性神经元发育的影响。Neuron migration is an integrated and multistep process, with high differentiation, polarization and orientation. This process plays an important role both in physiological and pathological processes. Lethal giant larvae 1(Lgl1), found in Drosophila, is one of tumor suppressors, and also has a critical role in regulation of proliferation, differentiation, tissue organization and cell polarity. This paper is review of the roles of Lgl1 in the development of olfactory bulb(OB) neurons, especially in the migration and orientation of typical neurons of lamellar structure.

关 键 词：Lgl1 嗅球 神经元 

分 类 号：Q13[生物学—普通生物学]