中药影响骨代谢分子机制研究进展  

Research progress on molecular mechanism of Chinese materia medica affecting bone metabolism

作　　者：张妍 王健英[2] 邢蕴蕴 刘锟 潘颖宜[1] 袁颖[1] ZHANG Yan;WANG Jian-ying;XING Yun-yun;LIU Kun;PAN Ying-yi;YUAN Ying(School of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Shanghai Innovation Center of TCM Health Service,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学中药学院,上海201203 [2]上海中医药大学协同创新中心,上海201203

出　　处：《中草药》2019年第20期5096-5102,共7页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81773922);上海中医药大学预算内课题(2016YSN10);第3批上海中医药大学中青年骨干教师教学能力提升资助计划(A1-U182050102060508)

摘　　要：骨代谢动态平衡是维持正常骨组织功能的重要因素之一,当平衡被打破,即造成骨损伤甚至骨代谢疾病。但目前骨代谢的机制尚不完全明确,影响骨代谢的信号通路复杂,疾病的治疗也尚在研究中。中医药对骨代谢的影响得到了越来越多的关注,探索中药影响骨代谢的机制成为治疗骨代谢疾病研究的新方向。目前在骨代谢中常见的机制有OPG/RANKL/RANK信号通路、Wnt/β-catenin信号通路、TGF-β/BMP/Smad信号通路及NF-κB信号通路等,综述中药对以上几种通路作用的研究进展,为进一步探索中药治疗骨代谢疾病提供参考。Dynamic balance of bone metabolism is one of the important factors to maintain normal osseous tissue function. When the balance is broken, it causes bone damage and even bone metabolic disease. However, the mechanism of bone metabolism is still unclear, the signal pathway is complex, and the treatment of diseases is still under study. The research on the mechanism of bone metabolism by Chinese materia medica has become a new direction in the treatment of bone metabolism diseases. At present, common mechanisms in bone metabolism include OPG/RANKL/RANK signal pathway, Wnt/β-catenin signal pathway, TGF-β/BMP/Smad signal pathway, and NF-κB signal pathway. In this paper, the research on the above pathways was reviewed, so as to provide a reference for further exploring the treatment of bone metabolism diseases with Chinese materia medica.

关 键 词：中药 骨代谢 OPG/RANKL/RANK信号通路 Wnt/β-catenin信号通路 TGF-β/BMP/Smad信号通路 核转录因子-κB信号通路 

分 类 号：R285[医药卫生—中药学]