老年男性人群血尿酸对心脑血管事件及全因死亡的影响  

Association Between Uric Acid and Risk of Cardiocerebral Diseases and All-cause Mortality in Elderly Men

作　　者：王丹 王剑利[2] 陈朔华 周靖[3] 李慧心 吴寿岭 WANG Dan;WANG Jianli;CHEN Shuohua;ZHOU Jing;LI Huixin;WU Shouling(Department of Neurology,Kailuan General Hospital,Tangshan(063000),Hebei,China)

机构地区：[1]作者单位:开滦总医院神经内科,河北省唐山市063000 [2]开滦总医院康复科,河北省唐山市063000 [3]开滦总医院肾内科,河北省唐山市063000 [4]开滦员工健康保障中心 [5]华北理工大学

出　　处：《中国循环杂志》2019年第11期1098-1102,共5页Chinese Circulation Journal

摘　　要：目的:探讨老年(≥60岁)男性人群血尿酸水平对心脑血管事件及全因死亡的影响。方法:采用前瞻性队列研究方法,选择参加2006~2007年开滦集团健康体检年龄≥60岁男性18202例职工为观察对象,以血尿酸三分位数值分为三组:第一分位组(血尿酸51~266μmol/L,n=6106)、第二分位组(血尿酸267~336μmol/L,n=6002)、第三分位组(血尿酸337~983μmol/L,n=6094)。平均随访(9.16±2.08)年,收集心脑血管疾病及全因死亡事件,应用Cox比例风险模型评估发病风险。结果:随访期间发生心脑血管事件2076例(11.41%),第一、二、三分位组分别为653例(10.69%)、634例(10.56%)、789例(12.95%);随访期间发生全因死亡事件4118例(22.62%),第一、二、三分位组分别为1254例(20.54%)、1344例(22.39%)、1520例(24.94%)。校正传统心血管疾病危险因素后,多因素Cox回归分析显示,与第一分位组相比,第二、三分位组发生心脑血管事件的RR值分别为1.01(95%CI:0.90~1.14)、1.24(95%CI:1.11~1.39),全因死亡的RR值分别为0.98(95%CI:0.91~1.06)、1.06(95%CI:0.98~1.14)。结论:基线血尿酸水平升高是老年男性人群心脑血管疾病的独立危险因素。Objectives:To investigate the association between serum uric acid level and risk of cardiocerebral diseases and all-cause death in elderly(≥60 years old)male population.Methods:18202 participants aged≥60 years,who took part in the 2006-2007 Kailuan health examination,were enrolled in this prospective,observational cohort study.The participants were classified into three groups based on the tertiles value of blood uric acid:first quintile(blood uric acid 51.0-266μmol/L,n=6106),second quintile(blood uric acid 267-336μmol/L,n=6002),and third quintile(blood uric acid 337-983μmol/L,n=6094).New-onset cardiocerebral diseases and all-cause mortality during followup(mean[9.16±2.08]years)were analyzed.Cox proportional hazard regression model was used to evaluate the association between uric acid level and outcomes.Results:A total of 2076(11.41%)cardiocerebral events occurred during the follow-up period,653(10.69%)cases in the first tertiles group,634(10.56%)cases in the second tertiles group,and 789(12.95%)cases in the third tertiles group.4118(22.62%)deaths occurred during the follow-up period,1254(20.54%)cases in the first tertiles group,1344(22.39%)cases in the second tertiles group,and 1520(24.94%)cases in the third tertiles group.Compared with first tertiles group,the multivariable adjusted relative risks associated with second tertiles,third tertiles group were 1.01(95%CI:0.90-1.14)and 1.24(95%CI:1.11-1.39.P<0.01)for cardiocerebral diseases events,and 0.98(95%CI:0.91-1.06),1.06(95%CI:0.98-1.14,P<0.01)for all-cause mortality,respectively.Conclusions:Elevated baseline serum uric acid levels are independent risk factors for cardiocerebral vascular disease in elderly men.

关 键 词：血尿酸 心脑血管病 死亡率 老年男性人群 

分 类 号：R54[医药卫生—心血管疾病]