三联药物方案对重型麻疹患者近期疗效与合并症的影响  

Effect of triple drug combination regimen on the clinical efficacy for short-term, immune system function and complications of patients with severe measles

作　　者：李达[1] 赵菊花[1] 何启敏[1] 王洁[1] 杨羽[1] LI Da;ZHAO Juhua;HE Qimin;WANG Jie;YANG Yu(Department of Dermatology,Nanchong Central Hospital,Nanchong637000,Sichuan,China)

机构地区：[1]川北医学院第二临床医学院·南充市中心医院皮肤科

出　　处：《西部医学》2019年第11期1753-1756,共4页Medical Journal of West China

基　　金：四川省卫生和计划生育委员会科研课题(18PJ421)

摘　　要：目的探讨三联药物方案对重型麻疹患者近期疗效、免疫系统功能及合并症的影响。方法选取我院2015年8月~2018年8月收治重型麻疹患者共150例,分为对照组和观察组,每组各75例。对照组予以利巴韦林联合复方甘草酸苷治疗,观察组在此基础上加用炎琥宁注射液。治疗2周后,比较两组患者近期疗效,症状体征消失时间,住院时间,治疗前后T淋巴细胞亚群水平及合并症发生率。结果观察组患者临床疗效显著优于对照组(P<0.05);观察组患者症状体征消失时间和住院时间均显著短于对照组(P<0.05);观察组患者治疗后T淋巴细胞亚群水平均显著优于对照组、治疗前(P<0.05);观察组患者合并症发生率显著低于对照组(P<0.05);观察组患者用药期间不良反应的总发生率低于对照组(P>0.05)。结论三联药物方案治疗重型麻疹患者可有效减轻临床症状体征,加快病情康复进程,改善机体免疫功能,并有助于降低合并症发生风险,安全性较高。Objective To investigate the effect of triple drug combination regimen on the clinical efficacy for short-term, immune system function and complications of patients with severe measles. Methods 150 patients with severe measles were chosen in the period from August 2015 to August 2018 in our hospital and randomly divided into both group including control group(75 cases) with ribavirin combined with Stronger Neo-Miaophagen C and observation group(75 cases) with Potassium Sodium Pehydroandroandrographolide Succinate injection on the basis of control group. The clinical efficacy for short-term, the disappearance time of symptoms and signs, the hospital staying time, the T lymphocyte subsets levels before and after treatment and the incidence of complications of both groups were compared. Results The clinical effects for short-term of observation group were significant better than that of control group(P<0.05). The disappearance time of symptoms and signs and the hospital staying time of observation group were significant better than that of control group(P<0.05). The T lymphocyte subsets levels after treatment of observation group was significant better than that of control group and before treatment(P<0.05). The incidence of complications of observation group were significant lower than that of control group(P<0.05). Conclusion Triple drug combination regimen on patients with severe measles can efficiently relieve the clinical symptoms and signs, speed up the recovery process of disease, improve immune function and be helpful to reduce the risk of complications.

关 键 词：利巴韦林 复方甘草酸苷 炎琥宁 重型麻疹 免疫功能 

分 类 号：R511.1[医药卫生—内科学]