2,2-二甲基-5-(4-氯苄基)环戊酮的合成  

Synthesis of 5-(4-Chlorobenzyl)-2,2-dimethylcyclopentanone

作　　者：沈方烈[1] 柯佳含 韦伟[1] SHEN Fang-lie;KE Jia-han;WEI Wei(Zhejiang Research Institute of Chemical Industry Co.,Ltd.,Hangzhou 310023,China)

机构地区：[1]浙江省化工研究院有限公司

出　　处：《农药》2019年第11期792-795,共4页Agrochemicals

摘　　要：[目的]合成叶菌唑的关键中间体2,2-二甲基-5-(4-氯苄基)环戊酮。[方法]以己二酸二甲酯为原料,经迪克曼缩合、苄基化、甲基化、脱羧4步反应合成2,2-二甲基-5-(4-氯苄基)环戊酮。[结果]反应总收率65.9%,产品纯度96.1%。[结论]方法步骤短、收率高、操作较简便,适合工业化放大。[Aims]The paper aims to synthesize 5-(4-chlorobenzyl)-2,2-dimethylcyclopentanone,a key intermediate for metconazole.[Methods]5-(4-Chlorobenzyl)-2,2-dimethylcyclopentanone was synthesized from dimethyl adipate by reactions of Dickmann condensation,benzylation,methylation and decarboxylation.[Results]The product was obtained in total yield of 65.9 with 96.1%purity.[Conclusions]The method has the advantages of short steps,high yield,and simple operation,it is suitable for industrial scale-up production.

关 键 词：叶菌唑 2 2-二甲基-5-(4-氯苄基)环戊酮 己二酸二甲酯 

分 类 号：TQ460.3[化学工程—制药化工]