环境暴露对儿童变态反应性疾病的影响  

Effects of environmental exposure on allergic diseases in children

作　　者：周小建[1] 洪建国[1] Zhou Xiaojian;Hong Jianguo(Department of Pediatrics,Shanghai General Hospital,Shanghai Jiaotong University,Shanghai 200080,China)

机构地区：[1]上海交通大学附属第一人民医院儿内科,200080

出　　处：《中华实用儿科临床杂志》2019年第21期1605-1611,共7页Chinese Journal of Applied Clinical Pediatrics

摘　　要：环境与基因的相互作用导致儿童变态反应性疾病的发病率逐年上升,环境暴露可动态影响变态反应性疾病的各种表型,包括特应性皮炎、哮喘、变应性鼻炎等。与变态反应性疾病相关的环境因素包括空气中的化学污染物、变应原及微生物组等其他环境暴露因素。室内外空气污染物及变应原在变应原引起的变态反应的炎性反应及临床表现中起重要作用。加强环境治理及控制环境暴露是防治变态反应性疾病的重要手段。The prevalence of allergic diseases is rising in children as a result of complex gene-environment interactions.Environmental exposures can dramatically influence the phenotype of allergic diseases,including atopic eczema,asthma,and allergic rhinitis.Environmental factors associated with allergic diseases include chemical pollutants and allergens in the air,as well as other environmental exposures such as the microbiome.Indoor and outdoor air pollutants and allergens play an important role in the inflammatory response and clinical manifestations of allergic reactions caused by allergens.Strengthening environmental control and controlling environmental exposure is an important way to prevent allergic diseases.

关 键 词：变态反应 空气污染 变应原 哮喘 特应性皮炎 环境暴露 微生物组 变应性鼻炎 

分 类 号：R76[医药卫生—耳鼻咽喉科]