加味柴牡四物颗粒治疗慢性心力衰竭临床疗效研究  

Clinical Efficacy of Using Modified Chaimu Siwu Granule in the Treatment of Chronic Heart Failure

作　　者：陈骏[1] 胡宏阳 龙坤兰 唐丹 郝燕民 杨霞琳 高培阳[1] CHEN Jun;HU Hongyang;LONG Kunlan(The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine(Chengdu Sichuan 610072,China;Chengdu University of Traditional Chinese Medicine(Chengdu Sichuan 610075,China)

机构地区：[1]成都中医药大学附属医院

出　　处：《四川中医》2019年第11期82-85,共4页Journal of Sichuan of Traditional Chinese Medicine

基　　金：四川省中医药管理局中医药科研青年专项项目(编号:2016Q021)

摘　　要：目的:观察加味柴牡四物颗粒治疗慢性心力衰竭的临床疗效。方法:采用随机、对照、双盲的方法,收集2016年7月~2017年12月我院收治的134例慢性心力衰竭患者,将符合纳入标准的患者采用双盲的研究方法随机分为两组(随机方法需描述),常规西医治疗(按照2014年中华医学会.心血管病学分会慢性心力衰竭中西医结合诊疗专家共识)+安慰剂组(65例)作为A组,在常规西医治疗基础上加用加味柴牡四物颗粒组(69例)作为B组。记录两组患者治疗前后、治疗1月、3月、6月及随访6月心血管原因导致的有效率、心衰相关急性事件、治疗前后NT-proBNP水平差值、NYHA分级、6MWD、随访期内心力衰竭急性发次数、明尼苏达心衰生活质量量表(MLHFQ)等,并进行统计分析。结果:治疗组有效率71.0%,对照组有效率52.3%,两组患者治疗后随访6个月两组治疗后血浆NT-pro BNP比较,差异有统计学意义(P<0.05):两组治疗前后NYHA分级、6MWD、明尼苏达心衰生活质量量表(MLHFQ)均有所改善,两组有统计学意义(P<0.05)。两组患者治疗中均未见明显不良反应。结论:慢性心力衰竭患者的临床治疗中,联合使用加味柴牡四物颗粒可以明显改善患者的临床症状,能够降低慢性心力衰竭患者NT-proBNP,减少心衰相关急性事件的发生及心衰急性发作次数,提高患者生活质量。Objective:To study the clinical effect of using Modified Chaimu Siwu Granule in the treatment of chronic heart failure. Methods:A randomized, controlled, double blind method was used to collect 134 patients with chronic heart failure admitted from July 2016 to December 2017. The patients were randomly divided into two groups. The conventional western medicine(According to the 2016 Chinese Medical Association, cardiology branch, expert consensus on diagnosis and treatment of chronic heart failure with integrated traditional Chinese and western medicine) plus placebo group(65 cases) was used as group A, based on conventional western medicine plus Modified Chaimu Siwu Granule group(69 cases) as B group. Records of the two groups of patients before and after treatment, treatment lasted 1 month, 3 months and 6 months were effective, fatality rate, left ventricular end diastolic diameter(LVEDD) and left ventricular ejection fraction(LVEF), NT-proBNP level difference before and after treatment, NYHA classification, 6 MWD. The number of acute onset of heart failure during the follow-up period, and the quality of life scale for heart failure(MLHFQ) in Minnesota. Results:The effective rate of the B group was 71%, and the effective rate in the group A was 52.3%. The difference in the group B was less than that in the group A(P<0.05). The difference of plasma NT Pro BNP in the two groups was statistically significant(P<0.05). There was no significant difference between the two groups of left ventricular ejection fraction(LVEF) and ventricular end diastolic diameter(LVEDd) before and after treatment(P>005), and NYHA grade, 6 MWD, and Minnesota heart failure quality of life(MLHFQ) were improved before and after treatment in the two groups, and the two groups were statistically significant(P<0.05). No obvious adverse reactions were observed in the two groups. Conclusion:In the treatment of chronic heart failure, combined use of Modified Chaimu Siwu Granule can obviously improve the clinical symptoms of patients, reduce the mort

关 键 词：慢性心力衰竭 加味柴牡四物颗粒 临床疗效 

分 类 号：R541.6[医药卫生—心血管疾病]