防治冠心病中药质量标志物的研究进展  

Research advances on quality markers of Chinese materia medica for prevention and treatment of coronary heart disease

作　　者：王朔[1] 解静[1] 李琳[1] 徐一兰[1] 高树明[1] 高杉[1] 于春泉[1] WANG Shuo;XIE Jing;LI Lin;XU Yi-lan;GAO Shu-ming;GAO Shan;YU Chun-quan(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学

出　　处：《中草药》2019年第19期4620-4627,共8页Chinese Traditional and Herbal Drugs

基　　金：国家重点基础研究计划(973计划)项目(2014CB542902)

摘　　要：冠心病是造成我国居民死亡及疾病负累的主要病因之一。中医药在对冠心病的认识及诊治方面显示出优势明显,大量临床及实验研究已证实中药对冠心病的疗效确切,防治冠心病的中药研究成为心血管研究领域的热点。中药质量是保证中药发挥其效用价值的关键因素,也是中药现代化、科学化的基本保障,中药质量标志物的提出,进一步明确了中药质量标准和控制方法,为促进中药新药研发,保证临床用药的安全性、有效性提供了研究思路。对防治冠心病中药研究、中药质量控制的方法及质量标志物等进行综述。Coronary heart disease(CHD) is one of the main causes of death and disease in China. Traditional Chinese medicine has shown advantages in the understanding and diagnosis of coronary heart disease. A large number of clinical and experimental studies have confirmed that Chinese medicine has definite effects on CHD. Chinese materia medica(CMM) research on prevention and treatment of CHD has become a focus in cardiovascular research. The quality of CMM is the key factor to ensure the value of CMM, and it is also the basic guarantee for the modernization and scientization of CMM. The quality of CMM is proposed to further clarify the quality standards and control methods of CMM, to promote the research and development of new Chinese medicines and to ensure clinical use. The safety, effectiveness and revealing the essential attributes of CMM provide research ideas. This article reviews the research on prevention and treatment of CMM for CHD, the quality control method of CMM, and the application status of quality markers.

关 键 词：冠心病 中药 质量标志物 心血管 临床用药 

分 类 号：R286.2[医药卫生—中药学]