吩嗪-1-羧酸及其类似物研究进展  

Research Progress of Phenazine-1-carboxylic Acid and Its Analogue

作　　者：朱祥[1] 吴清来[1,2] 李俊凯 Zhu Xiang;Wu Qinglai;Li Junkai(School of Agriculture,Yangtze University,Jingzhou 434025;Institute of Pesticides,Yangtze University,Jingzhou 434025)

机构地区：[1]长江大学农学院,荆州434025 [2]长江大学农药研究所,荆州434025

出　　处：《有机化学》2019年第10期2744-2758,共15页Chinese Journal of Organic Chemistry

基　　金：国家重点研发计划(No.2018YFD0200500);国家自然科学基金(No.31672069);长江大学优秀博士学位论文培育计划资助项目~~

摘　　要：吩嗪-1-羧酸是一种广泛存在于假单胞菌和链霉菌等微生物的次级代谢产物,对植物病原菌具有很好的抑制活性,同时兼具医用杀菌及抗肿瘤等活性.综述了吩嗪-1-羧酸的生物合成与化学合成,并对目前吩嗪-1-羧酸天然类似物以及化学合成类似物的生物活性研究进行了总结,为此类化合物的结构改造与活性研究提供参考.Phenazine-1-carboxylic acid(PCA)as a natural product widely exists in microbial metabolites of Pseudomonads and Streptomycetes,which displays potent inhibitory activities against plant pathogens,and has medical antibacterial and antitumor effects,and so on.In this review,the biosynthesis and chemosynthesis of phenazine-1-carboxylic acid are summarized.At the same time,the diverse biological evaluations of its biosynthetic and chemosynthetic analogues are summarized,which could provide reference for the study of structural modifications and biological activities of these analogues.

关 键 词：吩嗪-1-羧酸 类似物 研究进展 

分 类 号：O62[理学—有机化学]