5-(1-苯基-3-苯基丙基-2-炔基)-2,2-亚戊基-1,3-二噁烷-4,6-二酮衍生物的有效合成（英文）  

Efficent Synthesis of 5-(1-Phenyl-3-phenylprop-2-ynyl)-2,2-pentylidene-1,3-dioxane-4,6-dione Derivatives

作　　者：范乃立[1] 许招会[1] 向正兵 肖强[2] 廖传文[2] Fan Naili;Xu Zhaohui;Xiang Zhengbing;Xiao Qiang;Liao Chuanwen(Department of Chemistry and Chemical Engineering,Jiangxi Normal University,Nanchang 330027;Department of General Surgery,Jiangxi Province People's Hospital,Nanchang 330006)

机构地区：[1]江西师范大学化学化工学院,南昌330027 [2]江西省人民医院外科,南昌330006

出　　处：《有机化学》2019年第10期2892-2897,共6页Chinese Journal of Organic Chemistry

基　　金：Project supported by the Graduate Innovation Foundation of Jiangxi Province(No.YC2015-B023);the Science and Technology Research Project of Jiangxi Provincial Education Department(No.GJJ170170)~~

摘　　要：在醋酸铜/铜催化体系作用下,以醛、2,2-亚戊基-1,3-二噁烷-4,6-二酮和芳基乙炔为原料,发生包含Knoevenagel缩合与共轭加成反应的多组分反应,有效地合成了12种5-(1-苯基-3-苯基丙基-2-炔基)-2,2-亚戊基-1,3-二噁烷-4,6-二酮衍生物.该工艺具有收率高(65%~88%)、反应温和、操作简单及过量铜粉还能回收利用等优点.A convenient and efficient approach for the synthesis of 5-(1-phenyl-3-phenylprop-2-ynyl)-2,2-pentylidene-1,3-dioxane-4,6-dione derivatives through a three-component reaction of aldehydes with 2,2-pentylidene-1,3-dioxane-4,6-dione and arylacetylene in the presence of Cu(OAc)2 H2O/Cu is described with 12 examples.The reaction tolerates a wide range of aldehydes furnishing the products with good to excellent isolated yields(65%~88%).Additionally,the synthetic protocol has the advantages of wild conditions,simple operation,and excessive copper reused.

关 键 词：多组分反应 醋酸铜/铜 2 2-亚戊基-1 3-二噁烷-4 6-二酮 5-(1-苯基-3-苯基丙基-2-炔基)-2 2-亚戊基-1 3-二噁烷-4 6-二酮衍生物 

分 类 号：O62[理学—有机化学]