无过渡金属参与的三芳基膦化合物合成新方法研究  

A Novel Method for the Synthesis Triarylphosphines under Transition-Metal-Free Conditions

作　　者：尹清 于晓强[1] 包明[1] Yin Qing;Yu Xiaoqiang;Bao Ming(State Key Laboratory of Fine Chemicals,Dalian University of Technology,Dalian 116024)

机构地区：[1]大连理工大学精细化工国家重点实验室

出　　处：《有机化学》2019年第10期2930-2935,共6页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21572028,21573032)资助项目~~

摘　　要：三芳基膦化合物在医药合成、过渡金属催化等方面扮演十分重要的角色.报道了碱促进的芳基卤代物与烷基取代的二芳基膦的C(sp2)—P键偶联新方法合成三芳基膦.该方法具有无过渡金属催化剂参与、反应底物来源广泛、后处理简洁等优点.Triarylphosphines play an important role in pharmaceutical synthesis and transition-meal-catalyzed reactions.In this paper,a novel method for the synthesis of triarylphosphines via base-promoted C(sp2)—P cross-coupling reactions of alkyldiphenylphosphines with aryl halides is described.The transition-metal-free reaction condition,readily available starting materials and experimental simplicity are the features of the novel method.

关 键 词：无过渡金属 烷基取代的二芳基膦 芳基卤代物 三芳基膦化合物 

分 类 号：O62[理学—有机化学]