铁氢配合物对一级酰胺脱水成腈的催化作用  

Catalytic Effect of Iron Hydrides on Dehydration of Primary Amides to Nitriles

作　　者：郑婷婷 王洋洋[1,3] 杨在孝 孙宏建 李晓燕[1] Zheng Tingting;Wang Yangyang;Yang Zaixiao;Sun Hongjian;Li Xiaoyan(Key Laboratory of Special Functional Aggregated Materials,Ministry of Education,School of Chemistry and Chemical Engineering,Shandong University,Jinan 250100;Department of Chemistry,Capital Normal University,Beijing 100048;College of Chemistry and Chemical Engineering,Northwest Normal University,Lanzhou 730070)

机构地区：[1]山东大学化学与化工学院教育部特种功能聚集体材料重点实验室,济南250100 [2]首都师范大学化学系,北京100048 [3]西北师范大学化学化工学院,兰州730070

出　　处：《有机化学》2019年第10期2941-2945,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21372143)资助项目~~

摘　　要：主要研究了苯硒酚基铁氢配合物cis-[(ArSe)FeH(PMe3)4][Ar=Ph(1),p-MeOC6H4(2)和o-MeC6H4(3)]对一级酰胺脱水成腈的催化作用.实验证明当选用(EtO)3SiH为还原剂时,在较为温和的条件下这三种配合物均对一级酰胺脱水为腈的过程都具有良好的催化作用.该催化体系对于芳基酰胺中苯环上的取代基具有很好的耐受性.与斥电性基团相比,吸电性基团对该催化反应比较有利.Three cis-selenophenolato iron hydrides cis-[(ArSe)FeH(PMe3)4][Ar=Ph(1),p-MeOC6H4(2)and o-MeC6H4(3)],were used as catalysts for the dehydration of primary amides to nitriles.The experimental results show that three complexes have good catalytic effect on reductive dehydration of primary amide to nitrile under mild conditions using(EtO)3SiH as reducing agent.The catalytic system is well tolerated to the substituents on the benzene ring in aromatic amides.Compared with electron-donating group,electron-withdrawing group is more advantageous to the catalytic reaction.

关 键 词：铁氢配合物 硒酚 硒配位 酰胺脱水 腈制备 

分 类 号：O6[理学—化学]