两亲聚肽/螺烯的电荷复合自组装行为研究  

Study of Charge-Conjugated Self-Assembly Behavior of Amphiphilic Block Copolypeptides/Helicene

作　　者：王婧琳 沈程硕 唐颂超 姚远 Wang Jinglin;Shen Chengshuo;Tang Songchao;Yao Yuan(Teaching and Research Department of Polymer Materials and Engineering,School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237;School of Chemistry and Chemical Engineering,Shanghai Jiao Tong University,Shanghai 200240)

机构地区：[1]华东理工大学材料科学与工程学院高分子材料与工程教研室,上海200237 [2]上海交通大学化学化工学院,上海200240

出　　处：《有机化学》2019年第10期2973-2979,共7页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.51573088)资助项目~~

摘　　要：研究了包含聚肽嵌段的两亲共聚物聚乙二醇-b-聚(L-谷氨酸)(PEG-b-PGlu)与4-甲基-4-氮杂[4]螺烯鎓离子(Me[4]H)的电荷复合自组装行为,讨论了聚肽链段长度、谷氨酸单元与螺烯物质的量比、pH值等因素对组装体形貌的影响.研究发现,当刚-柔型嵌段聚合物与刚性、大尺寸并具有诱导作用的小分子共同组装时,遵循与柔性大分子电荷复合组装完全不同的规律.PEG-b-PGlu/Me[4]H的电荷复合组装体形貌由π-π堆叠作用、两亲嵌段聚肽的亲疏水比、PGlu链段的刚硬程度共同决定,这些作用在组装过程中相互制约,当π-π堆叠作用占主导地位时,得到以指针状和条带状等平面结构为主的组装形貌.Amphiphilic block copolypeptides of polyethylene glycol-b-poly(L-glutamic acid)(PEG-b-PGlu)were synthesized to self-assemble with 4-methyl-4-aza[4]helicene onium ion(Me[4]H)in water through charge-conjugation.The morphology of the assemblies was studied by varying PGlu block length,the molar ratio of Glu unit/Me[4]H and pH value.It was found that when rigid-flexible block copolymers were assembled together with small molecules which had rigid,large size and inductive effect,they would follow a completely different law from the charge-conjugated assembly of flexible macromolecules.The self-assemblies were controlled by theπ-πstacking of helicene,together with the volume fraction of the hydrophobic parts and the rigidity of PGlu segments.These effects restricted each other in the assembly process.Whenπ-πstacking was dominant,assembly morphologies with pointer-like and strip-like planar structures were obtained.

关 键 词：电荷复合自组装 两亲嵌段共聚物 螺烯 

分 类 号：TB3[一般工业技术—材料科学与工程]