The role of organic electron donors in the initiation of BHAS base-induced coupling reactions between haloarenes and arenes  

作　　者：Andrew J.Smith Darren L.Poole John A.Murphy 

机构地区：[1]Department of Pure and Applied Chemistry,University of Strathclyde,Strathclyde,Glasgow G11XL,United Kingdom [2]Flexible Discovery Unit,GlaxoSmithKline Medicines Research Centre,Stevenage,SG12NY,United Kingdom

出　　处：《Science China Chemistry》2019年第11期1425-1438,共14页中国科学（化学英文版）

基　　金：EPSRC;GSK;the University of Strathclyde for funding(AJS)

摘　　要：Coupling reactions between haloarenes and arenes(including heteroarenes)that are conducted without added transition metals but in the presence of KOtBu or NaOtBu,have been a topic of great interest since their discovery in 2008.Diverse organic structures act as additives that assist these reactions.These additives are converted into organic electron donors by the butoxide base and this leads to initiation of the coupling reactions,which proceed by radical chain mechanisms.This review provides an overview of the initiation stages of these reactions.Coupling reactions between haloarenes and arenes(including heteroarenes) that are conducted without added transition metals but in the presence of KOtBu or Na OtBu, have been a topic of great interest since their discovery in 2008. Diverse organic structures act as additives that assist these reactions. These additives are converted into organic electron donors by the butoxide base and this leads to initiation of the coupling reactions, which proceed by radical chain mechanisms. This review provides an overview of the initiation stages of these reactions.

关 键 词：ORGANIC ELECTRON donor potassium tert-butoxide ELECTRON transfer base-promoted homolytic AROMATIC substitution(BHAS) coupling BENZYNE 

分 类 号：O62[理学—有机化学]