血必净注射液联合异甘草酸镁治疗药物性肝损伤的临床研究  

Clinical study on Xuebijing Injection combined with magnesium isoglycyrrhizinate in treatment of drug-induced liver injury

作　　者：袁福兵[1] 王卫兵[1] 李妮[1] YUAN Fu-bing;WANG Wei-bing;LI Ni(Department of Infectious Disease,the 904th Hospital of the Joint Logistics Support Force of PLA,Wuxi 214044,China)

机构地区：[1]中国人民解放军联勤保障部队九〇四医院感染科

出　　处：《现代药物与临床》2019年第10期3102-3106,共5页Drugs & Clinic

摘　　要：目的探讨血必净注射液联合异甘草酸镁注射液治疗药物性肝损伤的临床疗效。方法选取2016年7月-2018年4月中国人民解放军联勤保障部队第904医院收治90例药物性肝损伤患者为研究对象,参照随机数表法分为对照组和治疗组,每组各45例。对照组静脉滴注异甘草酸镁注射液,150 mg加入5%葡萄糖注射液250 mL中,1次/d。治疗组在对照组治疗的基础上静脉滴注血必净注射液,100 mL加入0.9%氯化钠注射液100 mL中,1次/d。两组均连续治疗14 d。观察两组的临床疗效,比较两组的临床症状消失时间、肝功能指标、血清炎症因子水平。结果治疗后,对照组和治疗组的总有效率分别为68.89%、86.67%,两组比较差异有统计学意义(P<0.05)。治疗后,治疗组肝区不适、腹胀、纳差、乏力、恶心呕吐消失时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,两组天冬氨酸氨基转移酶(AST)、总胆红素(TBIL)、丙氨酸氨基转移酶(ALT)及碱性磷酸酶(ALP)水平均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);治疗后治疗组AST、TBIL、ALT、ALP水平均明显低于对照组,差异有统计学意义(P<0.05)。治疗后,两组血清肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)水平均显著下降,白细胞介素-10(IL-10)水平明显升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组血清TNF-α、IFN-γ、IL-10水平均明显优于对照组,差异有统计学意义(P<0.05)。结论血必净注射液联合异甘草酸镁注射液治疗药物性肝损伤具有较好的临床疗效,可改善临床症状和肝功能指标,减轻机体炎症反应,具有一定的临床推广应用价值。Objective To investigate the effects of Xuebijing Injection combined with Magnesium Isoglycyrrhizinate Injection in treatment of drug-induced liver injury. Methods Patients(90 cases) with drug-induced liver injury in the 904 th Hospital of the Joint Logistics Support Force of PLA from July 2016 to April 2018 were randomly divided into control and treatment groups, and each group had 45 cases. Patients in the control group were iv administered with Magnesium Isoglycyrrhizinate Injection, 150 mg added into 5% glucose solution 250 mL, once daily. Patients in the treatment group were iv administered with Xuebijing Injection on the basis of the control group, 100 mL added into normal saline 100 mL, one daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and the disappearance time of clinical symptoms, liver function indexes, and serum levels of inflammatory factors in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 68.89% and 86.67%, respectively, and there was difference between two groups(P < 0.05). After treatment, the disappearance time of liver discomfort, abdominal distension, poor appetite, fatigue and nausea and vomiting in the treatment group were significantly shorter than those in the control group, and there was difference between two groups(P < 0.05). After treatment, the levels of AST, TBIL, ALT, and ALP in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). And the liver function indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups(P < 0.05). After treatment, the levels of TNF-α and IFN-γ in two groups were significantly decreased, but the levels of IL-10 in two groups were significantly increased, and the difference was statistically significant in the same group(P < 0.05). And the serum levels of inflammatory factors in the trea

关 键 词：血必净注射液 异甘草酸镁注射液 药物性肝脏损伤 临床症状消失时间 肝功能 炎症因子 

分 类 号：R975[医药卫生—药品]