2-甲基-3-苯基苯甲酸的合成方法研究  

Synthesis Method Research of 2-Methyl-3-phenylbenzoic Acid

作　　者：王晓雅 黄星星 WANG Xiao-ya;HUANG Xing-xing(School of Chemistry and Chemical Engineering,Ankang University,Ankang 725000,China)

机构地区：[1]安康学院化学化工学院

出　　处：《化学试剂》2019年第11期1210-1213,共4页Chemical Reagents

基　　金：安康学院大学生创新创业训练项目(2018AKXY-046)

摘　　要：标题化合物是一种具有广泛应用前景的重要化工中间体,然而,关于标题化合物的合成研究报道很少。报道了两种新的合成标题化合物方法:1)以2-甲基-3-氯联苯为原料制备Grignard试剂,然后通入CO2水解来制备,产率94%;2)以2-甲基-3-苯基苯甲醇为原料用Jones试剂选择性氧化制备该化合物,产率99%。并研究了试剂的用量与反应时间及温度的关系。这两种新方法具有合成工艺简单、产率高、工艺绿色环保等优点。所得化合物经IR和1HNMR确认。The title compound is an important chemical intermediate with broad application prospect.However,the synthesis process of the title compound had been few reported.Two new methods for synthesizing of the title compound were reported.A kind of synthesis is to prepare Gringnard reagents from 2-methyl-3-chlorinated biphenyls,which are then fed with CO2 and hydrolyzed with the yield of 94%.Another approach is to selectively oxidize 2-methyl-3-phenylbenzyl methanol with Jones reagent to obtain the title compound with the yield of 99%.The relationship between the amount of reagent and reaction time and temperature was investigated.The results show that these two new methods have the advantages of simple synthesis,high yield and green process.The compounds were confirmed by IR and 1HNMR.

关 键 词：GRIGNARD试剂 Jones试剂 选择性氧化 2-甲基-3-苯基苯甲酸 

分 类 号：O625.5[理学—有机化学]