种植体周围炎生物膜的微生物群落多样性研究进展  

Advances in the diversity of peri-implantitis biofilm microbial communities

作　　者：王倩 胡欢 范芹 马锐 彭泽惠 刘建国 WANG Qian;HU Huan;FAN Qin;MA Rui;PENG Ze-Hui;LIU Jian-Guo(Special Key Laboratory of Oral Disease Research,Higher Education Institution in Guizhou Province,Research Center for Medicine and Biology,Zunyi Medical University,Zunyi,Guizhou 563006,China;Special Key Laboratory of Microbial Resources and Drug Development,Higher Education Institution in Guizhou Province,Research Center for Medicine and Biology,Zunyi Medical University,Zunyi,Guizhou 563006,China;School of Stomatology,Zunyi Medical University,Zunyi,Guizhou 563099,China)

机构地区：[1]遵义医科大学医学与生物学研究中心贵州省普通高等学校口腔疾病研究特色重点实验室,贵州遵义563006 [2]遵义医科大学医学与生物学研究中心贵州省普通高等学校微生物资源及药物开发特色重点实验室,贵州遵义563006 [3]遵义医科大学口腔医学院,贵州遵义563099

出　　处：《微生物学通报》2019年第11期3084-3090,共7页Microbiology China

基　　金：口腔疾病研究国家重点实验室开放课题(SKLOD2017OF09);遵义医学院优秀青年人才项目(17zy-002);贵州省普通高等学校科技拔尖人才项目(黔教合KY字[2016]080)~~

摘　　要：种植体周围炎是发生在骨性结合种植体周围组织的炎症,是由微生物引发的感染性疾病,可引起种植体周围支持组织丧失而导致种植失败。阐明种植体周围炎生物膜的微生物学基础,可为制定相应防治策略提供理论依据。随着测序技术的发展,基于16S rRNA基因的测序分析技术逐渐应用于与口腔种植体相关的微生物学研究,使人们对种植体周围炎生物膜的微生物群落多样性有了更全面的了解,也进一步认识到种植体周围炎和牙周炎菌斑生物膜的微生物结构存在显著差别。本文根据基于16S rRN基因A序列分析技术的最新研究成果,对种植体周围炎菌斑生物膜的微生物学研究进展作一综述。Peri-implantitis diseases are characterized by the presence of an inflammatory process that affects the peri-implant tissues under loading, caused by microorganisms and might lead to the implant failure. Investigations on the microbiota of peri-implant biofilm would be important to define effective preventive and therapeutic strategies for peri-implantitis. With the development of sequencing technology, sequencing and analysis technology of 16 S rRNA gene have recently been used to evaluate the microbiota associated with osseointegrated implants. These results expanded the knowledge on the diversity of the microbial communities associated with the disease;they also suggested that the microbial structure of peri-implantitis might be different with periodontitis. Here we review the recent progress about the microbiology of peri-implantitis biofilm based on 16 S rRNA gene sequence analysis technology.

关 键 词：种植体周围炎 菌斑生物膜 微生物群落 多样性 16S RRNA基因 

分 类 号：F11[经济管理—国际贸易]