表面介孔柞蚕丝素蛋白微球的制备及药物释放性能  

Preparation of Mesoporous Tussah Silk Fibroin Partilces and Their Drug Delivery Property

作　　者：杜姗 周伟涛[1,2] 张一敏 崔世忠 DU Shan;ZHOU Weitao;ZHANG Yimin;CUI Shizhong(School of Textiles.Zhongyuan University of Technology,Zhengzhou 4511911,China;Key Laboratory of Functional Textiles,the Education Department of Henan Province,Zhengzhou 451191,China)

机构地区：[1]中原工学院纺织学院,河南郑州451191 [2]河南省功能性纺织材料重点实验室,河南郑州451191

出　　处：《材料科学与工程学报》2019年第5期736-740,共5页Journal of Materials Science and Engineering

基　　金：国家自然科学基金资助项目(21671204);河南省高等学校重点科研资助项目(18A540003);中原工学院青年骨干教师培养计划项目(2018XQG03)

摘　　要：采用自组装的方法,以再生柞蚕丝素蛋白(RTSF)溶液为基体制备表面介孔柞蚕丝素蛋白微球,研究了缓释药物五氟尿嘧啶(5-FU)缓释量对微球粒径的影响、微球粒径与晶相转化之间的关系。研究表明,柞蚕丝素蛋白微球为近似球形,基本无粘连,其粒径大小为500nm^6μm且表面具有形状规则均匀的多孔结构;晶相结构主要以β-折叠为主,同时存在无规卷曲结构;表面多孔TSF微球对5-FU缓释能力显著,在120h能有效释放90%,并且较宽的粒径分布和多孔结构更有助于药物释放速率的控制。This research focused on the preparation of mesoporous regenerated tussah silk fibroin(RTSF) spheres via self-assembled method in solutions. To do an overall research on the spheres, the effects of the particle size on the release quantity of 5-FU, and the relationship between particle size and phase transformation were first studied. Results indicate that the spherical RTSF particles have little adherence with diameters from 500 nm to 6μm;its phase conformation is mainly β-sheet, with a little random coil. Meanwhile, the Mesoporous TSF microspheres show a good capacity of sustained drug release, with 95% initial loading over 120 h. Both wide size distribution and porous structure of the particles are more beneficial to the controlling of the drug release rate. These results reveal that the RTSF sphere is promising as a new type of gene medicines delivery system.

关 键 词：柞蚕 丝素蛋白 介孔 微球 药物释放 

分 类 号：O631[理学—高分子化学]