人源抗体制备及临床应用研究进展  

Research Progress in Preparation and Clinical Application of Therapeutic Human Antibodies

作　　者：陈秀秀 吴成林 周丽君 CHEN Xiu-xiu;WU Cheng-lin;ZHOU Li-jun(Department of Naval Clinical Medicine,Anhui Medical University,Beijing 100048,China;Central Laboratory of the Sixth Medical Center,General Hospital of the Chinese People’s Liberation Army,Beijing 100048,China)

机构地区：[1]安徽医科大学海军临床学院,北京100048 [2]中国人民解放军总医院第六医学中心中心实验室,北京100048

出　　处：《中国生物工程杂志》2019年第10期90-96,共7页China Biotechnology

基　　金：国家自然科学基金(31470897、81602457)资助项目

摘　　要：与常规治疗药物相比,抗体药物具有靶向性强、特异性好等优点,其作为一类重要的治疗性药物,近年来在临床中的应用逐渐增多,为疾病的治疗提供了新的选择,应用范围逐渐从肿瘤、自身免疫性疾病及慢性炎症扩展到心血管和感染性等疾病中。人源抗体的全部结构是由人类抗体基因所编码的,因此避免了异种蛋白长期应用引起的不良反应,加之人源抗体制备技术的不断发展完善,使其逐渐成为治疗性抗体研发的首要选择。综述了近年来治疗性人源抗体的主要制备技术及其在临床中应用的最新进展,同时探讨了人源抗体制备技术的不足之处,以期为人源抗体的发展提供借鉴和思路。As important therapeutic drugs,human antibodies have been widely applied in clinical therapy in recent years.At present,the range of clinical application has gradually expanded from tumors,autoimmune diseases and chronic inflammation to cardiovascular diseases and infection,Compared with conventional therapy,the advantages of antibody therapy are specificity and high efficiency,which provides a new choice for the treatment of diseases.The entire structure of the human antibody is encoded by the human antibody gene,the human antibody gradually becomes the first choice for the development of therapeutic antibodies for avoiding the adverse reactions caused by the long-term application of the heterologous protein.The main preparation techniques and clinical application progress of therapeutic human antibodies are reviewed.At the same time,the disadvantages of human antibody preparation technology are also discussed to provide references and ideas for the development of human antibodies.

关 键 词：人源抗体 噬菌体展示技术 转基因鼠技术 临床应用 

分 类 号：R392[医药卫生—免疫学]