健胃愈疡片联合左氧氟沙星对消化性溃疡患者血清转化生长因子α、胃泌素及超敏C反应蛋白水平的影响  

Effect of Jianwei Yuyang Tablets combined with levofloxacin on TGF-α, Gas and hs-CRP levels in patients with peptic ulcer

作　　者：曹媛[1] 张来启[2] CAO Yuan;ZHANG Laiqi(Pharmaceutical Preparation Department,Yulin Second Hospital,Yulin 719000,China;Gastroenterology Department,Yulin Second Hospital,Yulin 719000,China)

机构地区：[1]榆林市第二医院药剂科,陕西榆林719000 [2]榆林市第二医院消化内科,陕西榆林719000

出　　处：《药物评价研究》2019年第10期2062-2065,共4页Drug Evaluation Research

摘　　要：目的探讨健胃愈疡片联合左氧氟沙星片对消化性溃疡患者血清转化生长因子-α(TGF-α)、胃泌素(Gas)及超敏C反应蛋白(hs-CRP)水平的影响。方法选择回顾性研究的方法,选取2015年7月-2018年7月榆林市第二医院120例消化性溃疡患者,根据给药方案将受试者分为对照组(60例)和观察组(60例)。其中对照组患者口服左氧氟沙星片,0.5 g/次,1次/d。观察组患者在对照组的基础上口服健胃愈疡片,1.5 g/次,1次/d。两组均连续治疗1个月。治疗1个月后,观察两组患者的临床疗效,同时比较两组治疗前后的症状评分、TGF-α、Gas及hs-CRP水平变化、幽门螺旋杆菌(Hp)清除率及不良反应发生情况。结果治疗后,观察组治疗总有效率为93.33%,显著高于对照组的75.00%,两组比较差异具有统计学差异(P<0.01)。治疗后,两组患者的腹痛、腹胀、反酸、嗳气评分及总症状评分均较治疗前显著下降,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,观察组症状评分显著低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,观察组患者Hp清除率显著高于对照组,不良反应总的发生率显著低于对照组(P<0.05)。结论健胃愈疡片联合左氧氟沙星片可有效改善患者的临床症状,疗效安全显著,对促进消化性溃疡患者病情康复具有积极意义。Objective To explore the effects of Jianwei Yuyang Tablets combined with Levofloxacin Tablets on TGF-α, Gas and hsCRP levels in patients with peptic ulcer. Methods Selecting the method of retrospective study, 120 patients with peptic ulcer in Yulin Second Hospital from July 2015 to July 2018 were and devided into control(60 cases) and observation(60 cases) groups according to the dosage regimen. Patients in control group were po administered with Levofloxacin Tablets, 0.5 g/time, once daily.Patients in observation group were po administered with Jianwei Yuyang Tablets, 1.5 g/time, once daily. Patients in two groups were treated for 1 month. After 1 month of treatment, the clinical efficacy was observed, and symptom scores, the changes of TGF-α, Gas and hs-CRP levels, Hp clearance rate and adverse reactions before and after treatment were compared between two groups. Results The total effective rate in the observation group was 93.33%, which was significantly higher than 75.00% in the control group, and there was difference between two groups(P < 0.01). After treatment, the symptom scores of abdominal pain, abdominal distension,acid reflux, belching and total symptoms in two groups were significantly higher than those before treatment, and the difference was statistically significant in the same group(P < 0.05). After treatment, the symptom scores in the observation group were significantly lower than those in the control group, with significant difference between two groups(P < 0.05). After treatment, the levels of Gas and hs-CRP in two groups were significantly lower than those before treatment, the level of TGF-α was significantly higher than that before treatment, and the difference was statistically significant in the same group(P < 0.05). And the improvement level of each index of the observation group was significantly better than the control group,with significant difference between two groups(P <0.05). After treatment, the Hp clearance rate in the observation group was significantly higher than those i

关 键 词：健胃愈疡片 左氧氟沙星片 消化性溃疡 Hp清除率 不良反应 

分 类 号：R969[医药卫生—药理学]