丹参川芎嗪注射液联合常规用药治疗慢性心力衰竭的Meta-分析  

Meta-analysis of Salvia Miltiorrhiza Ligustrazine Injection combined with conventional medication in treatment of chronic heart failure

作　　者：葛梦雪 封亚丽[2] 张献献 吕璐 何红涛[2] GE Mengxue;FENG Yali;ZHANG Xianxian;LV Lu;HE Hongtao(Hebei University of Traditional Chinese Medicine,Shijiazhuang 050091,China;Department of Cardiovascular Medicine,Hebei Hospital of Traditional Chinese Medicine,Shijiazhuang 050000,China)

机构地区：[1]河北中医学院,河北石家庄050091 [2]河北省中医院心血管科,河北石家庄050000

出　　处：《药物评价研究》2019年第10期2084-2091,共8页Drug Evaluation Research

基　　金：河北省科技厅健康医疗与生物医药专项（18277783D）

摘　　要：目的评价丹参川芎嗪注射液联合常规用药治疗心力衰竭的疗效和安全性。方法系统地检索Cochrane Library、Pubmed、Web of Science、Embase、万方数据库(Wanfang)、中国学术期刊全文数据库(CNKI)、中国生物医学文献数据库(SinoMed)和维普中文期刊全文数据库(VIP)中丹参川芎嗪注射液联合常规用药治疗心力衰竭的随机对照研究(RCT)。检索时限从建库至2018年12月6日,提取资料,并使用Review Manager 5.3软件进行Meta-分析。结果共纳入18项RCTs,共1548例患者。Meta-分析结果显示:丹参川芎嗪注射液联合常规用药在临床疗效[OR=3.33,95%CI(2.39~4.63),P<0.00001]、提升射血分数[SMD=1.05,95%CI(0.27~1.83),P=0.009]、下调B型脑钠肽(BNP)水平[SMD=–1.22,95%CI(–2.03~–0.41),P=0.003]、升高每搏排血量[SMD=1.28,95%CI(0.19~2.38),P=0.02]和心脏指数[SMD=1.44,95%CI(0.50~2.38),P=0.003]方面均优于常规用药组,未见明显不良反应。结论丹参川芎嗪注射液联合常规用药治疗心力衰竭疗效优于常规用药,但由于纳入研究样本量较少、文献质量较低,其治疗心力衰竭的疗效需要更多高质量的临床研究加以证实。Objective To evaluate the efficacy and safety of Salvia Miltiorrhiza Ligustrazine Injection combined with conventional drugs in the treatment of chronic heart failure.Methods Systematic search of Cochrane Library,Pubmed,Web of Science,Embase,Wanfang database,China Academic Journal Full-text Database(CNKI),China Biomedical Literature Database(SinoMed)and Weipu Chinese Journal Full-text Database(VIP).Search the randomized controlled trial(RCT)about Salvia Miltiorrhiza Ligustrazine Injection combined with conventional drugs in the treatment of chronic heart failure.The search date was from the establishment of the database to December 6,2018.The data was extracted and Meta-analysis was performed using Review Manager 5.3 software.Results A total of 1548 patients were included in 18 RCTs.Meta-analysis.results Salvia Miltiorrhiza Ligustrazine Injection combined with conventional drugs in clinical efficacy[OR=3.33,95%CI(2.39-4.63),P<0.00001],elevated ejection fraction[SMD=1.05,95%CI(0.27-1.83),P=0.009],lower BNP levels[SMD=–1.22,95%CI(–2.03-–0.41),P=0.003],elevated blood intake per beat(SMD=1.28,95%CI(0.19-2.38),P=0.02]and heart index[SMD=1.44,95%CI(0.50-2.38),P=0.003],and other aspects are superior to the conventional drug group,no obvious adverse reactions.Conclusion The efficacy of Salvia Miltiorrhiza Ligustrazine Injection combined with conventional drug treatment is better than conventional drug use,but because the small sample size and lower literature quality in the stud,the curative effect of Salvia Miltiorrhiza Ligustrazine Injection in the treatment of heart failure needs more high-quality clinical research to confirm.

关 键 词：丹参川芎嗪注射液 慢性心力衰竭 B型脑钠肽 META-分析 

分 类 号：R972[医药卫生—药品]