妊娠期糖尿病妇女血浆脂肪酸结合蛋白4水平与妊娠高血压和先兆子痫发生的关系  

Relationship between fatty-acid binding protein 4 and gestational hypertension and preeclampsia in women with gestational diabetes mellitus

作　　者：李园春[1] 马颖[1] 赵晶[1] 郭君丽[2] LI Yuanchun;MA Ying;ZHAO Jing;GUO Junli(Department of Obstetrics Baoji Maternal and Child Health Care Hospital,Baoji,721000,China;Department of Gynaecology,Baoji Maternal and Child Health Care Hospital)

机构地区：[1]宝鸡市妇幼保健院产科,陕西宝鸡721000 [2]宝鸡市妇幼保健院妇科

出　　处：《临床血液学杂志（输血与检验）》2019年第5期773-776,共4页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

摘　　要：目的:探讨妊娠期糖尿病(GDM)妇女血浆脂肪酸结合蛋白4(FABP4)水平与妊娠高血压和先兆子痫(GH/PE)发生的关系。方法:选择2014-01—2017-12住院治疗的50例GDM并发GH/PE患者纳入研究(GH/PE组),选择同期50例年龄、孕龄、妊娠前体质指数(BMI)相接近的GDM未并发GH/PE妇女患者作对照(非GH/PE组)。采用ELISA法检测患者血浆FABP4水平,并收集患者临床资料进行分组及统计学分析。结果:GH/PE组与非GH/PE组比较,2组血浆FABP4水平差异有统计学意义[(17.2±4.1)μg/L vs(11.6±3.3)μg/L,t=7.605,P=0.000]。所有入组患者中血浆FABP4水平与妊娠前BMI,孕中期BMI,孕龄,糖化血红蛋白(HbA1c),HOMA-IR,MAP呈正相关(r=0.241~0.582,均P<0.05);非GH/PE组患者中血浆FABP4水平与妊娠前BMI,孕中期BMI,HOMA-IR呈正相关(r=0.341~0.611,均P<0.05);GH/PE组患者中血浆FABP4水平与妊娠前BMI,孕中期BMI呈正相关(r=0.521,0.534,均P<0.05)。多因素Logistic回归分析结果显示,血浆FABP4水平是影响GDM妇女GH/PE发生的危险因素(OR=1.212,95%CI 1.002~1.402,P=0.032)。结论:血浆FABP4水平在GDM并发GH/PE妇女中显著升高,可能与GDM女性GH/PE发生相关。Objective:To investigate the relationship between FABP4 and GH/PE in women with GDM.Method:50 patients of GH/PE in women with GDM in hospital from Jan 2014 to Dec 2017 were selected as the GH/PE group,50 women with GDM but without GH/PE,whose age,gestational age and pre-pregnancy BMI were similar,were selected as the non-GH/PE group.Plasma FABP4 levels were measured by ELISA,and other clinical data were collected for statistical analysis.Result:There was a significant difference in plasma FABP4 level between GH/PE group and non-GH/PE group[(17.2±4.1)μg/L vs(11.6±3.3)μg/L,t=7.605,P<0.05].Plasma FABP4 levels in all patients were positively correlated with pre-pregnancy BMI,mid-pregnancy BMI,gestational age,HbA1 c,HOMA-IR and MAP(r=0.241-0.582,all P<0.05).The plasma FABP4 levels in non-GH/PE group were positively correlated with pre-pregnancy BMI,mid-pregnancy BMI and HOMA-IR(r=0.341-0.611,all P<0.05).Plasma FABP4 levels in group GH/PE were positively correlated with pre pregnancy BMI and mid pregnancy BMI(r=0.521,0.534,all P<0.05).Multivariate logistic regression analysis showed that plasma FABP4 was a risk factor for GH/PE in GDM women(OR=1.212,95%CI 1.002-1.402,P=0.032).Concluson:Plasma FABP4 level is significantly elevated in GDM women with GH/PE,and closely related to the occurrence of GH/PE in GDM women.

关 键 词：脂肪酸结合蛋白4 妊娠期糖尿病 妊娠高血压 先兆子痫 

分 类 号：R714.24[医药卫生—妇产科学]