Globoside血型抗原研究进展  

Research progress of globoside blood group antigen

作　　者：胡氏月 李树中(审校)[1] 李中华 吴建红[1] 范春丽[1] 李凌波 HU Shiyue;LI Shuzhong;LI Zhonghua

机构地区：[1]江苏大学附属昆山医院,江苏昆山215300 [2]黑龙江省牡丹江市第二人民医院 [3]长春博讯生物技术有限责任公司

出　　处：《临床血液学杂志（输血与检验）》2019年第5期813-817,共5页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

摘　　要：Globoside(GLOB)抗原是糖苷类抗原,2010年国际输血协会(ISBT)确认为血型系统抗原,系统命名为GLOB,系统编号是028,该系统有2个抗原。GLOB系统抗原经历了漫长时间的研究和定义上的混乱,经过了数次改名和系统变更。1抗原的命名和发展史1.1 GLOB1抗原1955年Sanger等发现了一种与P抗原相关的Tj a抗原。他们把Tj a抗原命名为P抗原,把Tj(a-)红细胞表型命名为P-表型,即P-表型红细胞上没有Tj a抗原(即没有P抗原),把Tj(a+)表型红细胞命名为P+表型,即P+表型红细胞上有Tj a抗原(即有P抗原)。但是这与Landsteier发现的P抗原和P表型的命名重叠了,为了区分两者,ISBT进行了更改命名;将Landsteier发现的P抗原更改命名为P1抗原,相应的P+表型红细胞更改为P1表型,将P-表型更改为P2表型。The GLOB antigen is a system that has been renamed several times,changed several times,and was finally recognized as a systemic antigen for red blood cells by ISBT in 2010.The GLOB antigen belongs to the glycoside antigen and is synthesized with PK antigen as a precursor.This antigen is also a precursor antigen of NOR antigen,FORS antigen and LKE antigen.The GLOB antigen gene is polymorphic and generally occurs in exon 5.The GLOB antigen is a receptor for the B19 parvovirus and is involved in the red blood cell immune mechanism.The anti-GOLB1 antibody is a relatively rare antibody and has the nature of a D-L antibody and is a causative antibody for spontaneous abortion.

关 键 词：GLOB血型抗原 糖苷脂抗原 基因多态性 B19细小病毒受体 自发性习惯性流产 新生儿溶血病 

分 类 号：R556.6[医药卫生—血液循环系统疾病]