美托洛尔联合曲美他嗪治疗冠心病心力衰竭的效果评价  

Evaluation on effect of metoprolol combined with trimetazidine in the treatment of coronary heart disease and heart failure

作　　者：康红 KANG Hong(Department One of Internal Medicine,Jinzhou Linghai People’s Hospital,Jinzhou 121200,China)

机构地区：[1]辽宁省锦州市凌海市人民医院内一科

出　　处：《中国实用医药》2019年第33期4-6,共3页China Practical Medicine

摘　　要：目的观察冠心病心力衰竭患者采用美托洛尔+曲美他嗪治疗的临床效果。方法78例冠心病心力衰竭患者,采用随机数字表法分为实验组和对照组,各39例。对照组患者采用常规治疗,实验组患者在对照组基础上采用美托洛尔+曲美他嗪治疗。比较两组患者治疗效果,治疗前后收缩压、舒张压、心率,左心室射血分数、左心室收缩和舒张末期内径。结果实验组总有效率为97.44%,高于对照组的82.05%,差异有统计学意义(P<0.05)。治疗前,两组收缩压、舒张压及心率对比,差异无统计学意义(P>0.05);治疗后,两组收缩压、舒张压及心率均低于治疗前,且实验组收缩压(112.1±6.5)mm Hg(1mm Hg=0.133 kPa)、舒张压(74.4±5.5)mm Hg及心率(76.5±5.4)次/min均低于对照组的(124.4±6.6)mm Hg、(84.6±4.8)mm Hg、(84.3±1.6)次/min,差异有统计学意义(P<0.05)。治疗前,两组左心室射血分数、左心室收缩和舒张末期内径对比,差异无统计学意义(P>0.05);治疗后,两组左心室射血分数、左心室收缩和舒张末期内径优于治疗前,且实验组均优于对照组,差异有统计学意义(P<0.05)。结论针对冠心病心力衰竭采用美托洛尔+曲美他嗪治疗,可明显提高临床效果,改善患者各项指标水平。Objective To observe the clinical effect of metoprolol combined with trimetazidine in the treatment of patients with coronary heart disease and heart failure.Methods A total of 78 patients with coronary heart disease and heart failure were divided into experimental group and control group according to random number table method,with 39 cases in each group.The control group received conventional therapy,and the experimental group received metoprolol combined with trimetazidine for treatment on the basis of the control group.Comparison was made on therapeutic effect,systolic blood pressure,diastolic blood pressure,heart rate,left ventricular ejection fraction,left ventricular end systolic and diastolic diameter before and after treatment between the two groups.Results The total effective rate was 97.44%in the experimental group,which was higher than 82.05%in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in systolic blood pressure,diastolic blood pressure,heart rate between the two groups(P>0.05).After treatment,the systolic blood pressure,diastolic blood pressure,heart rate in the two groups was lower than those before treatment.The systolic blood pressure,diastolic blood pressure,heart rate were(112.1±6.5)mm Hg(1 mm Hg=0.133 kPa),(74.4±5.5)mm Hg and(76.5±5.4)times/min in the experimental groups,which was lower than(124.4±6.6)mm Hg,(84.6±4.8)mm Hg and(84.3±1.6)times/min in the control group.Their difference was statistically significant significant(P<0.05).Before treatment,there was no statistically significant difference in left ventricular ejection fraction,left ventricular end systolic and diastolic diameter between the two groups(P>0.05).After treatment,the left ventricular ejection fraction,left ventricular end systolic and diastolic diameter in the two groups was better than those before treatment,and the the experimental group was better than those in the control group.Their difference was statistically sign

关 键 词：冠心病 心力衰竭 美托洛尔 曲美他嗪 

分 类 号：R54[医药卫生—心血管疾病]