血清肝素结合蛋白与降钙素原联合检测对急诊恶性肿瘤患者早期细菌感染的诊断价值  

The value of serum heparin binding protein and procalcitonin in the detection of early infection in patients with emergency malignant tumor

作　　者：杨勋能[1] 张军建[1] 任勇[1] YANG Xunneng;ZHANG Junjian;REN Yong(Department of Emergency,the Third People's Hospital of Zigong,Zigong,Sichuan,643020,China)

机构地区：[1]自贡市第三人民医院急诊科

出　　处：《临床急诊杂志》2019年第10期771-774,共4页Journal of Clinical Emergency

摘　　要：目的:探讨血清肝素结合蛋白(HBP)与降钙素原(PCT)联合检测对急诊恶性肿瘤患者早期细菌感染诊断的价值。方法:回顾性分析我院急诊科2017-01—2019-01期间就诊的已确诊的120例恶性肿瘤患者的临床资料,根据是否并发细菌感染将其分为感染组(62例)及非感染组(58例)。均于入院后采集外周静脉血,测定两组HBP与PCT含量。以受试者工作特征(ROC)曲线评价HBP和PCT及两者联合对恶性肿瘤患者早期细菌感染的诊断价值。结果:感染组HBP及PCT均高于非感染组(P<0.05);HBP、PCT及联合检测的AUC分别为0.881、0.861及0.934,联合检测的AUC大于单一检测HBP或PCT的AUC(P<0.05);HBP、PCT及联合检测的灵敏度分别为72.6%、56.5%及88.7%,特异度分别为86.3%、94.8%及89.7%,联合检测灵敏度高于单一检测HBP或PCT的灵敏度;联合检测特异度高于单一检测HBP的特异度。结论:HBP与PCT联合检测对急诊恶性肿瘤患者早期细菌感染具有良好的诊断效能,优于单一指标的诊断价值,可提高诊断的灵敏度。Objective:To investigate the value of serum heparin binding protein(HBP)and procalcitonin(PCT)in the detection of early infection in patients with emergency malignant tumor.Method:The clinical data of 120 patients with confirmed malignant tumors in the emergency department of the Third People’s Hospital of Zigong City from January 2017 to January 2019 were retrospectively analyzed.According to whether bacterial infections occur,they were divided into infection group(n=62 cases)and non-infection group(n=58 cases).Peripheral venous blood was collected after admission and the levels of serum HBP and PCT were measured in both groups.Receiver operating characteristic(ROC)curve was used to evaluate the diagnostic value of serum HBP combined with serum PCT for early bacterial infection in patients with malignant tumors.Result:Serum HBP and PCT in infection group were higher than those in non-infection group(P<0.05).The AUC of HBP,PCT and HBP combine with PCT were 0.881,0.861 and 0.934 respectively.The AUC of combined detection of HBP and PCT detection was higher than that of single detection of HBP or PCT(P<0.05).The sensitivity of HBP,PCT and combined detection were 72.6%,56.5%and 88.7%respectively.The specificity of HBP,PCT and combined detection were 86.3%,94.8%and 89.7%respectively.The sensitivity of combined detection is higher than that of single detection of HBP or PCT.The specificity of combined detection was higher than that of single detection of HBP.Conclusion:The combined detection of HBP and PCT has a good diagnostic efficacy for early bacterial infection in patients with malignant tumors in emergency department,which is superior to the diagnostic value of a single index and can improve the diagnostic sensitivity.

关 键 词：肝素结合蛋白 降钙素原 恶性肿瘤 细菌感染 

分 类 号：R459.7[医药卫生—急诊医学]