腹腔感染患者病原菌检出情况及耐药性分析  

Detection of pathogenic bacteria and analysis of drug resistance in patients with abdominal infection

作　　者：张静[1] 赵新惠[1] 刘洁[1] Zhang Jing;Zhao Xinhui;Liu Jie(Clinical Laboratory,Binzhou Central Hospital,Binzhou 251700,China)

机构地区：[1]滨州市中心医院检验科,251700

出　　处：《国际医药卫生导报》2019年第22期3761-3763,共3页International Medicine and Health Guidance News

摘　　要：目的分析腹腔感染患者病原菌检出情况及耐药性。方法回顾性分析本院2016年1月至2018年12月期间收治的腹腔感染患者临床相关资料,收集患者腹腔标本,并进行病原菌培养及药敏试验。结果送检标本共4629次,其中540次培养呈阳性,阳性率为11.67%,共包含582株病原菌,其中革兰氏阴性菌355株,革兰氏阳性菌201株,真菌26株;大肠埃希菌与肺炎克雷伯菌对三代头孢菌素耐药率较高,对碳青霉烯类、阿米卡星及替加环素的耐药性较低;鲍曼不动杆菌对多种常用抗菌药物的耐药率均处于较高水平,铜绿假单胞菌对常用抗菌药物的耐药性均较低;屎肠球菌对青霉素、环丙沙星耐药性较高,对万古霉素、利奈唑胺的耐药率较低,粪肠球菌对常用抗菌药物的耐药性均较低;金黄色葡萄球菌与表皮葡萄球菌均对青霉素及三代头孢耐药性较高。结论腹腔感染患者所感染的病原菌种类繁多,病原菌总体耐药形式严峻,临床上应积极进行细菌培养及药敏试验,了解病原菌分布及耐药情况,合理选择抗菌药物。Objective To analyze the detection and drug resistance of pathogenic bacteria in patients with abdominal infection.Methods The clinical data of patients with abdominal infection admitted to our hospital from January 2016 to December 2018 were retrospectively analyzed.Peritoneal specimens were collected and pathogenic bacteria culture and drug sensitivity test were carried out.Results A total of 4629 samples were sent for examination,540 of which were cultured positive,with a positive rate of 11.67%.There were 582 strains of pathogenic bacteria,including 355 strains of Gram-negative bacteria,201 strains of Gram-positive bacteria,and 26 strains of fungi.Escherichia coli and Klebsiella pneumoniae were more resistant to third-generation cephalosporins than to carbapenems,amikacin,and tigecycline.The resistance rates of Acinetobacter baumannii to many commonly used antimicrobial agents were at a high level,and the resistance of Pseudomonas aeruginosa to commonly used antimicrobial agents were low.Enterococcus faecium was more resistant to penicillin and ciprofloxacin,less resistant to vancomycin and linezolid,and Enterococcus faecalis was less resistant to commonly used antimicrobial agents.Staphylococcus aureus and Staphylococcus epidermidis were both more resistant to penicillin and third-generation cephalosporins.Conclusion There are many kinds of pathogenic bacteria in patients with abdominal infection,and the drug resistance of pathogenic bacteria is severe.We should actively carry out bacterial culture and drug sensitivity test in clinic to understand the distribution and drug resistance of pathogenic bacteria,and rationally select antibiotics.

关 键 词：腹腔感染 病原菌 检出情况 耐药性 

分 类 号：R44[医药卫生—诊断学]