新型炎症因子在结缔组织病中的研究  

Study on Novel Inflammatory Factors in Connective Tissue Diseases

作　　者：李淅萌 聂英坤[1] LI Xi-meng;NIE Ying-kun(Department of Rheumatology and Immunology,the Second Affiliated Hospital of Harbin Medical University,Harbin 150000,Heilongjiang,China)

机构地区：[1]哈尔滨医科大学附属第二医院风湿免疫科

出　　处：《医学信息》2019年第22期24-26,42,共4页Journal of Medical Information

基　　金：黑龙江省自然科学基金项目(编号：D200975)

摘　　要：结缔组织病(CTD)泛指结缔组织受累的自身免疫性疾病,目前病因尚不明确,一般认为与遗传、感染及免疫异常等因素相关,其主要致病机制为非特异性炎症反应。疾病诊断主要依靠临床表现及实验室检查,随着风湿免疫学发展,多种新型炎症因子逐渐应用到自身免疫病的诊断与疾病活动度评估中,这些新型炎症因子包括中性粒/细胞淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)、红细胞分布宽度(RDW)等,本文将对NLR、PLR及RDW在CTD中的相关研究展开综述,以期为临床医务人员对CTD进行诊断和活动性评估提供参考依据。Connective tissue disease(CTD)refers to the autoimmune diseases involved in connective tissue.The current cause is not clear.It is generally considered to be related to genetic,infection and immune abnormalities.The main pathogenic mechanism is non-specific inflammatory response.The diagnosis of diseases mainly depends on clinical manifestations and laboratory tests.With the development of rheumatic immunology,a variety of new inflammatory factors are gradually applied to the diagnosis of autoimmune diseases and the assessment of disease activity.These new inflammatory factors include neutrophil lymphocyte ratios(NLR),platelet lymphocyte ratio(PLR),red blood cell distribution width(RDW),etc.This article will review the related research of NLR,PLR and RDW in CTD,in order to diagnose and evaluate CTD for clinical medical staff to provide a reference basis.

关 键 词：中性粒细胞/淋巴细胞比值 血小板/淋巴细胞比值 红细胞分布宽度 结缔组织病 

分 类 号：R593.2[医药卫生—内科学]