增生性瘢痕分子信号通路研究  

Study on Molecular Signaling Pathway of Hypertrophic Scar

作　　者：韩玉丽 刘琪琪 李真 辛燕 HAN Yu-li;LIU Qi-qi;LI Zhen;XIN Yan(Graduate School of Inner Mongolia Medical University,Hohhot 010110,Inner Mongolia,China;Department of Dermatology and Venereology,the Third Clinical Medical College,Inner Mongolia Medical University,Baotou014010,Inner Mongolia,China)

机构地区：[1]内蒙古医科大学研究生学院,内蒙古呼和浩特010110 [2]内蒙古医科大学第三临床医学院皮肤性病科,内蒙古包头014010

出　　处：《医学信息》2019年第22期31-34,共4页Journal of Medical Information

基　　金：内蒙古自治区自然科学基金项目(编号：2017MS0815)

摘　　要：增生性瘢痕是临床常见的皮肤纤维增生性疾病,因伤口过度愈合而形成的。其从外观和机体功能方面均给患者带来心理和生理上的痛苦,严重者甚至影响患者自信心,使其产生自卑心理。增生性瘢痕的形成机制虽未完全清楚,但伴随着相关研究的不断深化,目前关于该病发病机制的研究已经进入到细胞、分子和基因水平。其中转化生长因子-β1信号通路、磷脂酰肌醇3激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白信号通路、Hippo信号通路、Notch信号通路和Hedgehog信号通路参与了增生性瘢痕的形成过程,本文主要就上述信号通路在增生性瘢痕发病机制中的研究做一综述,旨在为进一步认识增生性瘢痕的发病机制提供参考。Hypertrophic scar is a common clinical skin fibrosis disease,which is formed by excessive wound healing.It brings psychological and physical pain to the patient in terms of appearance and body function.In severe cases,it even affects the patient’s self-confidence and makes them feel inferior.Although the formation mechanism of hypertrophic scar is not fully understood,with the continuous deepening of related research,the current research on the pathogenesis of the disease has entered the cellular,molecular and genetic levels.Transforming growth factor-β1 signaling pathway,phosphatidylinositol 3 kinase/protein kinase B/mammalian rapamycin target protein signaling pathway,Hippo signaling pathway,Notch signaling pathway and Hedgehog signaling pathway are involved in the formation of hypertrophic scar This article mainly reviews the above-mentioned signaling pathways in the pathogenesis of hypertrophic scars,aiming to provide a reference for further understanding the pathogenesis of hypertrophic scars.

关 键 词：增生性瘢痕 分子信号通路 TGF-Β1 

分 类 号：R622[医药卫生—整形外科]