2型糖尿病患者脆性骨折风险的发病机制  

Pathogenesis of fragility fracture in patients with type 2 diabetes

作　　者：王瑞灯 贾璞[1] 唐海[1] WANG Rui-deng;JIA Pu;TANG Hai(Department of Orthopedics,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院骨科

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2019年第5期538-543,共6页Chinese Journal Of Osteoporosis And Bone Mineral Research

摘　　要：2型糖尿病是一个日益严重的全球健康问题。近年来大量的研究发现2型糖尿病患者脆性骨折风险增加。脆性骨折风险增高的机制目前认为可能与跌倒风险增加、骨强度下降、高血糖状态、细胞因子以及降糖药物等有关。当前对于2型糖尿病与脆性骨折之间的关系仍在探索之中。本文旨在对当前关于2型糖尿病患者脆性骨折风险增加相关机制的研究做一综述。Type 2 diabetes is a growing global health problem.In recent years,a large number of studies have found that patients with type 2 diabetes have an increased risk of fragility fractures.The mechanism is thought to be associated with increased risk of falls,decreased bone strength,hyperglycemia,cytokines,and antidiabetic drugs et al.The association between type 2 diabetes and fragility fractures is still being explored.This article aims to summarize the pathogenesis of increased risk of fragility fractures in patients with type 2 diabetes.

关 键 词：2型糖尿病 骨密度 骨强度 脆性骨折 

分 类 号：R681[医药卫生—骨科学]