前列地尔对重症急性胰腺炎患者早期促炎因子的影响观察  

Effect of alprostadil on early proinflammatory factors in patients with severe acute pancreatitis

作　　者：袁伟红[1] 张征[1] Yuan Weihong;Zhang Zheng(Department of Gastroenterology Yixing People's Hospital,Yixing,Jiangsu 214200,China)

机构地区：[1]宜兴市人民医院消化内科,江苏宜兴214200

出　　处：《医药前沿》2019年第31期25-27,共3页Journal of Frontiers of Medicine

基　　金：无锡市卫生计生委科研项目(MS201804).

摘　　要：目的:观察前列地尔对重症急性胰腺炎患者早期促炎因子的影响.方法:随机将我院收治的重症急性胰腺炎患者55例分成两组,参照组27例患者实施常规基础治疗,治疗组28例患者在常规基础治疗的前提下加用前列地尔治疗,对比两组重症急性胰腺炎患者的治疗效果.结果:两组重症急性胰腺炎患者治疗后的IL-6、IL-1β、TNF-α及治疗优良率存在显著差异(P<0.05),有统计学意义.结论:针对重症急性胰腺炎患者实施前列地尔治疗,效果显著,促进患者早期促炎因子的改善,减轻炎症损伤,提高治疗效果.Objective To observe the effect and efficacy of alprostadil on early proinflammatory factors in patients with severe acute pancreatitis.Methods A total of 55 patients with severe acute pancreatitis admitted to our hospital were randomly divided into two groups.27 patients in the reference group were given routine basic treatment.28 patients in the treatment group were treated with alprostadil under the premise of routine basic treatment.Compare the therapeutic effects of two groups of patients with severe acute pancreatitis.Results The levels of IL-6,IL-1β,TNF-αand therapeutic efficacy in patients with severe acute pancreatitis were significantly different(P<0.05),which was statistically significant.Conclusion The efficacy of alprostadil in patients with severe acute pancreatitis is significant,which can promote the improvement of early pro-inflammatory factors,reduce inflammatory damage and improve the therapeutic effect.

关 键 词：前列地尔 重症急性胰腺炎 促炎因子 有效性 

分 类 号：R322.491[医药卫生—人体解剖和组织胚胎学]