缬沙坦联合氨氯地平治疗高血压肾病的疗效评价  

Effect of angiotensin receptor blocker valsartan combined with amlodipine in the treatment of hypertensive nephropathy

作　　者：房星星[1] 陈冬梅[1] 沈燕[1] 沈良兰[1] FANG Xing-xing;CHEN Dong-mei;SHEN Yan;SHEN Liang-lan(Department of Nephrology,the Second Affiliated Hospital of Nantong University,Nantong 226000,China)

机构地区：[1]南通大学第二附属医院肾内科

出　　处：《基础医学与临床》2019年第12期1756-1759,共4页Basic and Clinical Medicine

摘　　要：目的探讨血管紧张素受体阻滞剂缬沙坦联合氨氯地平治疗高血压合并肾病的价值。方法选取2015年1月至2018年6月在南通大学第二附属医院就诊的84例患者纳入本研究。随机分为观察组和对照组,各42例。对照组给予缬沙坦治疗,观察组给予缬沙坦联合氨氯地平治疗。观察患者治疗后血压及肾功能主要指标的变化情况。结果观察组干预后收缩压(SBP)、舒张压(DBP)、尿素氮(BUN)、肌酐(Scr)和24 h尿蛋白水平均低于干预前(P<0.05),对照组干预后SBP、DBP、BUN、Scr和24 h尿蛋白水平均低于干预前(P<0.05)。观察组与对照组相比,BUN、Scr和24 h尿蛋白水平均低于对照组(P<0.05)。结论使用缬沙坦治疗高血压合并肾病具有较好控制血压,保护肾功能的作用,而缬沙坦联合氨氯地平治疗与单独使用缬沙坦相比具有更为显著的降压及肾功能保护的效果。Objective To investigate the effect of angiotensin receptor blocker valsartan combined with amlodipine in the treatment of hypertensive nephropathy.Methods Totally 84 patients admitted to the Second Affiliated Hospital of Nantong University from January 2015 to June 2018 were included in this study.They were randomly divided into observation group and control group,42 cases each.The control group was treated with valsartan only,while the observation group was treated with valsartan and amlodipine.The changes of blood pressure and renal function indexes were observed after treatment.Results The level of SBP,DBP,urea nitrogen(BUN),creatinine(Scr)and 24 h urinary protein in the observation group was lower than those before intervention(P<0.05),while the levels of SBP,DBP,BUN,Scr and 24 h urinary protein in the control group were lower than those before intervention(P<0.05).Compared with the control group,BUN,Scr and 24 h urine protein levels were lower than those of the control group(P<0.05).Conclusions Valsartan can control blood pressure and protect renal function in the treatment of hypertension nephropathy.Valsartan combined with amlodipine has better therapeutic effect than valsartan alone.

关 键 词：缬沙坦 氨氯地平 高血压肾病 

分 类 号：R320.2435[医药卫生—人体解剖和组织胚胎学]